Analysis of regional wall motion during contrast-enhanced dobutamine stress echocardiography: effect of contrast imaging settings.
Cosyns B, Van Camp G, Droogmans S, Weytjens C, Schoors D, Lancellotti P.
Despite the similar improvement in endocardial border delineation, LVO settings allow the detection of more WMA than MCE at peak stress, leading to a significantly higher accuracy for the detection of ischaemia in patients suspected of coronary artery disease when only wall motion is taken into account.
Reference: Eur J Echocardiogr. 2009 Dec;10(8):956-60
Real-time 3-dimensional echocardiography early after acute myocardial infarction: Incremental value of echo-contrast for assessment of left ventricular function.
Gaetano Nucifora, Nina Ajmone Marsan, Eduard R. Holman, Hans-Marc J. Siebelink, Jacob M. van Werkhoven, Arthur J. Scholte, Ernst E. van der Wall, Martin J. Schalij, Jeroen J. Bax
Assessment of LV systolic function in AMI patients with RT3DE is frequently hampered by suboptimal echocardiographic quality. Contrast-enhanced RT3DE is of incremental value, improving the endocardial border visualization and the reproducibility of LV function assessment.
Reference: American Heart Journal, Volume 157, Issue 5, May 2009, Pages 882.e1-882.e8
Impact of contrast echocardiography on evaluation of ventricular function and clinical management in a large prospective cohort.
Kurt M, Shaikh KA, Peterson L, Kurrelmeyer KM, Shah G, Nagueh SF, Fromm R, Quinones MA, Zoghbi WA
The utilization of CE in technically difficult cases improves endocardial visualization and impacts cardiac diagnosis, resource utilization, and patient management.
Reference: J Am Coll Cardiol. 2009 Mar 3;53(9):802-10
Left ventricular volume measurement with echocardiography: a comparison of left ventricular opacification, three-dimensional echocardiography, or both with magnetic resonance imaging.
Jenkins C, Moir S, Chan J, Rakhit D, Haluska B, Marwick TH, FESC.
A comparison of enhanced and non-enhanced contrast 2DE and 3DE with MRI as gold standard. The main findings of this study of patients with previous infarction are that the improvement in accuracy of estimation of LV volume and EF with CE-2DE is analogous to that of NC-3DE, and that techniques led to similar improvement in categorization of patients according to EF. However, CE-3DE is feasible and technically superior to NC-2DE, NC-3DE, and CE-2DE.
Reference: Eur Heart J 2009;30:98-106
A Randomized Cross-Over Study for Evaluation of the Effect of Image Optimization With Contrast on the Diagnostic Accuracy of Dobutamine Echocardiography in Coronary Artery Disease The OPTIMIZE Trial.
Plana JC, Mikati IA, Dokainish H, Lakkis N, Abukhalil J, Davis R, Hetzell, Zoghbi W.
There was no impact of contrast agent use on the agreement of dobutamine stress
echocardiography (DSE) with angiography (accuracy) if the confidence of interpretation
was high in unenhanced studies. However, a significant impact was seen when the con-
fidence of interpretation was low, with an intermediate effect in studies with medium
Reference: J Am Coll Cardiol Img 2008;1:145–52
Analysis of myocardial perfusion or myocardial function for detection of regional myocardial abnormalities. An echocardiographic multicenter comparison study using myocardial contrast echocardiography and 2D echocardiography.
Hoffmann R, FESC, Borges AC, Kasprzak JD, FESC, von Bardeleben S, Firschke C, FESC, Greis C,
Engelhardt M, Becher H, Vanoverschelde JL.
Qualitative estimation of myocardial perfusion contrast echo is inferior to contrast enhanced 2D echocardiography with regard to visibility of all LV segments and appears slightly inferior with regards to interobserver agreement (IOA), while both are superior to unenhanced 2D echocardiography. The methods demonstrated high accuracy in detection of panel defined regional myocardial abnormalities.
Reference: Eur J Echocardiogr 2007;8:438–448
Analysis of regional left ventricular function by cineventriculography, cardiac magnetic resonance imaging, and unenhanced and contrast-enhanced echocardiography: a multicenter comparison of methods
Hoffmann R, FESC, von Bardeleben S, Kasprzak JD, FESC, Borges AC, ten Cate F, FESC, Firschke C, FESC, Lafitte S, Al-Saadi N, Kuntz-Hehner S, Horstick G, Greis C, Engelhardt M, Vanoverschelde JL, FESC, Becher H.
Comparison of conventional and contrast-enhanced echocardiography, biplane cine angiography, and cardiac magnetic resonance for the detection of regional wall motion abnormalities. The study underlines the utility of contrast-enhanced echocardiography in comparison to the other methods. Although some limitations due to patients selection and the absence of data regarding the baseline quality of echocardiographic images, an unexpected lesson from this study arose with the interpretation of cardiac magnetic resonance imaging, showing an interobserver agreement much worse than expected.
Reference: J Am Coll Cardiol. 2006 Jan 3;47(1):121-8
Contrast administration reduces interobserver variability in determination of left ventricular ejection fraction in patients with left ventricular dysfunction and good baseline endocardial border delineation
Nayyar S, Magalski A, Khumri TM, Idupulapati M, Stoner CN, Kusnetzky LL, Coggins TR, Morris BA, Main ML, FESC.
This study has shown improved interobserver variability even in patients with good baseline endocardial border definition.
Reference: Am J Cardiol. 2006 Oct 15;98(8):1110-4
Other topics related to Contrast
- Historical & Landmark Papers
- Contrast for improving LV structural & functional assessment
- MCE for detection of myocardial ischaemia
- MCE for detection of myocardial viability
- MCE reviews & guidelines
- Safety of contrast agents
- Methodological Issues/Technique
- Left Ventricular Volumes and Regional Wall Motion
- Myocardial Perfusion