2025 Focused Update of the 2019 ESC/EAS Guidelines for the management of dyslipidaemias

ESC Clinical Practice Guidelines

29 Aug 2025

This 2025 Focused Update addresses changes in recommendations for the treatment of dyslipidaemias based on new evidence published since the 2019 version, up until 31 March 2025.

The Task Force also considered and discussed: combination therapy with high-dose statin plus ezetimibe and intensification of lipid-lowering therapy during the index hospitalization for patients presenting with acute coronary syndrome (ACS), as well as new data on lipoprotein(a) [Lp(a)] as a risk modifier.

Only results that would lead to new or changed Class I/IIa or Class III recommendations were selected for inclusion in Recommendation Tables.

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Topic(s):

Coronary Artery Disease (Chronic)

Cardiovascular Disease in Primary Care

Rehabilitation and Sports Cardiology

Basic Science

Treatment

Hypertension

Lipids

Risk Factors and Prevention

Cardiovascular Pharmacotherapy

Endorsed by cardiac societies

Armenian Cardiologists Association , Austrian Society of Cardiology , Belgian Society of Cardiology , Croatian Cardiac Society , Czech Society of Cardiology , Estonian Society of Cardiology , French Society of Cardiology , Georgian Society of Cardiology , German Cardiac Society , Hungarian Society of Cardiology , Irish Cardiac Society , Italian Federation of Cardiology , Association of Cardiologists of Kazakhstan , Kosovo Society of Cardiology , Kyrgyz Society of Cardiology , Latvian Society of Cardiology , Luxembourg Society of Cardiology , Maltese Cardiac Society , National Society of Cardiology of North Macedonia , Polish Cardiac Society , Romanian Society of Cardiology , San Marino Society of Cardiology , Cardiology Society of Serbia , Slovak Society of Cardiology