2. Normal and abnormal general physiology and heart EP, including ion channels, cellular EP, autonomous system influences, and the basic mechanisms of rhythm disorders, syncope, and sudden death

Antzelevitch C1, Burashnikov A. Overview of Basic Mechanisms of Cardiac Arrhythmia.Card Electrophysiol Clin. 2011 Mar 1;3(1):23-45.• Antzelevitch C1, Burashnikov A. Overview of Basic Mechanisms of Cardiac Arrhythmia.Card Electrophysiol Clin. 2011 Mar 1;3(1):23-45.
# Review basic mechanisms for cardiac arrhythmias, including channelopathies. Very good overview and great read to start up.

Nattel S, Dobrev D. Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation. Nat Rev Cardiol. 2016 Oct;13(10):575-90. doi: 10.1038/nrcardio.2016.118. Epub 2016 Aug 4.
# Comprehensive review on electrophysiologic fundamentals for paroxysmal atrial fibrillation.

Chen, P.-S., Chen, L. S., Fishbein, M. C., Lin, S.-F., & Nattel, S. Role of the Autonomic Nervous System in Atrial Fibrillation. Circulation Research, 114(9), 1500–1515. doi:10.1161/circresaha.114.303772
# Review on the mechanisms of interaction between the ANS, cardiac rhythm and pro arrhythmia (especially atrial fibrillation). Includes overview on potential therapeutic options (Sympathetic and Vagal Denervation; Ganglionated Plexus Ablation; Vagal Nerve Stimulation, among others).

Nattel S, Maguy A, Le Bouter S, Yeh Y-H. Arrhythmogenic Ion-Channel Remodeling in the Heart: Heart Failure, Myocardial Infarction, and Atrial Fibrillation. Physiol Rev 87: 425–456, 2007; doi:10.1152/physrev.00014.2006
# Review on ion channel remodelling in different disease subset and its relevance for proarrhythmia (heart failure, myocardial infarction, and atrial fibrillation).

Maurits Allessie, Jannie Ausma, Ulrich Schotten. Electrical, contractile and structural remodeling during atrial fibrillation. Cardiovascular Research 54 (2002) 230–246.
# Landmark paper reviewing the relation between electrical, contractile and structural and remodeling with AF and its duration.

Rubart, M. Mechanisms of sudden cardiac death. Journal of Clinical Investigation, 115(9), 2305-2315.
# Review on basic mechanisms underlying sudden cardiac death due to arrhythmia, including the role of aberrant intracellular Ca2+ handling, ionic imbalances associated with acute myocardial ischemia, neurohumoral changes and genetic predisposition. Therapeutic measures to prevent SCD are also discussed.

Whalley DW1, Wendt DJ, Grant AO. Basic concepts in cellular cardiac electrophysiology: Part I: Ion channels, membrane currents, and the action potential. Pacing Clin Electrophysiol. 1995 Aug;18(8):1556-74.
# Very Comprehensive review on basic principles on cardiac electrical action potential generation including abnormal automaticity.