Comment on the above paper
Chronic kidney disease (CKD) is an important risk factor for cardiovascular outcome. In the present study, Hakeem et al studied a large cohort of patients (n=1652) with suspected CAD who underwent stress MPS and an evaluation of kidney function (by means of calculation of eGFR). At baseline 36% had CKD defined as an eGFR < 60 ml/min/1.73m². After a mean follow-up op 2 years both renal function and MPS showed incremental predictive power for cardiac death prediction over baseline risk factors and left ventricular dysfunction. Importantly, patients with CKD had a relatively less benign prognosis that those without CKD, even in the presence of a normal scan.