In order to bring you the best possible user experience, this site uses Javascript. If you are seeing this message, it is likely that the Javascript option in your browser is disabled. For optimal viewing of this site, please ensure that Javascript is enabled for your browser.
Did you know that your browser is out of date? To get the best experience using our website we recommend that you upgrade to a newer version. Learn more.

High-dose adenosine overcomes the attenation of myocardial perfusion reserve caused by caffeine

Nuclear Imaging


Comment on the above paper

A common problem in patients referred for adenosine stress testing with myocardial perfusion imaging is the use of caffeine in the hours before adenosine is administered.  Reyes et al convincible show that caffeine in coffee indeed attenuates adenosine-induced coronary hyperemia in humans and, consequently, the detection of perfusion abnormalities by adenosine MPS.   However, they also show that this effect can be overcome by increasing the adenosine dose from 140 ug/kg/min to 210 ug/kg/min, without additional clinical side effects.


  1. Reyes E, Loong C, Harbinson M et al.  High dose adenosine overcomes the attenuation of myocardial perfusion reserve caused by caffeine.  J Am Coll Cardiol 2008;52:2008-16.
The content of this article reflects the personal opinion of the author/s and is not necessarily the official position of the European Society of Cardiology.