ALDH2 rs671 variant enhances platelet activation and thrombosis by disrupting mitochondrial complex I assembly
Cardiovascular Research
A common genetic variant may quietly amplify thrombotic risk. This study examines how the prevalent East Asian ALDH2 rs671 loss-of-function variant affects platelet biology. Using mouse models and CAD patients, the authors show that ALDH2 deficiency disrupts mitochondrial complex I, increases ROS signaling, and markedly enhances collagen-induced platelet activation and thrombosis. Importantly, NAD⁺ supplementation reversed platelet hyperreactivity, highlighting a potential, genotype-guided strategy to reduce thrombotic risk in clinical practice.
