Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) patients as well as genotype positive/phenotype patients are recommended to avoid high intensity and competitive sports according to the European Society of Cardiology guidelines based on an increased risk of sudden death and deleterious effect on the myocardium.1–3   

On the other hand, these patients should not be excluded to the clear benefits of low-to-moderate physical activity and cardiologist with expertise in cardiomyopathies should provide exercise prescription adapted to the underlying cardiac condition but also to patients’ goals. This brief article is aiming to help regarding this challenging issue.  

Baseline assessment 

Tailored exercise prescription should always start from a baseline assessment of the severity of the disease with a special attention to arrhythmic risk. Previous history of syncope, frequent ventricular ectopies (> 500/24h), significant structural involvement (i.e: right ventricular systolic dysfunction, or fibrosis) and exercise-induced complex ventricular arrhythmias are identified risk factors:  in the presence of them only low or very low intensity exercise could be prescribed. In the opposite, Moderate-intensity exercise can be considered in patients with very low arrhythmic risk.2 In the gray zone, exercise testing can help especially for patients planning to engage in moderate or intense physical activity beyond recommendations. Careful clinical and rhythmic evaluation and follow-up remain mandatory for such patients. Despite evidence about the role of sport in ARVC is mostly based on enriched PKP2 cohorts, recommendations are extensive to other ARVC cases irrespective of the genetic substrate.