Aims
This study will assess the proportion of MMVD including each combination of multiple and mixed VHD in a multicentre registry of all consecutive patients assessed on a cardiovascular imaging department for VHD. Furthermore, as secondary objectives, baseline characteristics, decision-making and therapeutic strategy at baseline and their impact in terms of prognostic and change in quality of life.
Methods
This is a prospective multicentre observational (“real-life”) study will be conducted as a cohort study with a 1-year follow-up. Consecutive patients with a diagnosis of MMVD by echocardiography who meet the inclusion criteria will be included during the 6 months period of recruitment. In the context of a “real-life” cohort, baseline evaluation will be left to the discretion of the attending physician (and could encompass clinical evaluations, biomarkers, electrocardiograms, transthoracic and transesophageal echocardiography, cardiac catheterization, invasive angiography, cardiac CT, and CMR). Final diagnosis of the physician will be given, and the physician will manage the patient in accordance with their local guidelines. One year follow-up will be performed during a patient visit or by contact with the treating physician or the patient: vital status, hospitalizations for cardiac reasons (including HF), QoL questionnaire, history of stroke and the performance of a new valvular intervention.
Expected results and perspectives
The primary endpoint will be the proportion of MMVD among all patients admitted for VHD evaluation in the imaging department. Secondary endpoints encompass; (i) epidemiologic distribution of clinical, biological and cardiovascular imaging characteristics at baseline. (ii) proportion of MMVD treated by surgery, percutaneous or medical as well as the detail for management and how complication are managed and (iii) Prognostic evaluation at one year of follow-up in terms of clinical composite outcome, all-cause mortality, hospitalisation for heart failure and change in quality of life.
Conclusions
This is the first prospective multicentre study assessing the proportion of MMVD and their characteristics in terms of diagnosis, management, and prognostic.
