Translation of genomics into routine cardiological practice

Location: Marriott Munich Airport Hotel

Thursday, 23 March 14:00 - Friday, 24 March 2023 12:00 CET (2 Days)

23/03/2023 14:00 24/03/2023 12:00 Europe/Paris Translation of genomics into routine cardiological practice

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In-person
event

Summary

A workshop chaired by Profs. Stefanie Dimmeler and Perry Elliott, Dr. Leticia Ferri (BMS), Dr. Paul Nioi (Alnylam) and Dr. Chris O’Donnell (Novartis).

Resources

Session 1

Session 2

Session 3

Session 4

Session 5

Programme

View faculty biographies

DAY 1: 23 March 2023 - 14:00 - 18:45

Time	Session	Speaker
Session 1 – Exemplars of translation into clinical practice and lessons learnt Chaired by Chris O'Donnell and Heribert Schunkert
14:00 - 14:10	Welcome - Introduction - Objectives of the Workshop To prepare a short position paper describing: Current state of the art in genetic diagnostics and therapy. Describe the current and future barriers to translation. Propose an action plan to accelerate into routine care.	Chairpersons
14:10 - 14:30	What is precision cardiology?	*Perry Elliott (London)*
14:30 - 14:45	PCSK9 and beyond	*Ulf Landmesser (Berlin)*
14:45 - 15:00	Cardiac Amyloidosis	Thibaut Damy (Paris)
15:00- 15:45	Breakout Groups & Feedback/discussion (1) What does success look like?	Moderators
Session 2 – CURRENT STATE OF THE ART: CHALLENGES FOR GENE THERAPY Chaired by Filippo Crea and Paul Nioi
15:45 - 16:00	Challenges for gene therapies: Delivery, durability and complications	*Mauro Giacca (London)*
16:00 - 16:15	Gene therapy and Gene editing Examples of successful translation	*Christian Kupatt (Munich)*
16:15 - 16:30	RNA Therapeutics	*Weinong Guo (Alnylam)*
16:30-17:15	Breakout Groups and Feedback/discussion (2) 1. What are the main technical/biological barriers to be overcome? 2. What can we do collectively to accelerate translation to patients?	Moderators
*17:15 - 17:30*	*Break*
Session 3 – DIAGNOSTICS: POLYGENIC RISK SCORES Chaired by Stefanie Dimmeler and Perry Elliott
17:30 - 17:45	Debate: Polygenic risk scores are ready for application in routine cardiological practice.	Pro: Maryam Kavousi (Rotterdam)
17:45 - 18:00	Debate: Polygenic risk scores are ready for application in routine cardiological practice.	Con: *Heribert Schunkert (Munich)*
18:00 - 18:45	Panel and audience discussion “How to overcome the gaps in translation – What are the critical issues?”	All
	Short rebuttal
	VOTE BY AUDIENCE FOR/AGAINST THE MOTION
18:45 – End of Day 1 - Outlook to Day 2

DAY 2: 24 March 2023 - 09:00 - 12:00

Time	Session	Speaker
Session 3 (cont’d) – DIAGNOSTICS: POLYGENIC RISK SCORES Chaired by Leticia Ferri and Eva Prescott
09:00 - 09:15	Summary of Day 1 – Main outcomes from the breakout discussions	Chairpersons
09:15 - 09:45	What is the landscape for approval and licensing of genomic therapies (EMA, MHRA) E. ZOURIDAKIS - Regulatory aspects-Genomic therapies	*Antonio Gomez-Outes (Spain)* *Emmanouil Zouridakis, UK MHRA*
09:45 - 10:45	Breakout Groups and Feedback/discussion (3) How do we prioritize diseases for gene therapy? What are meaningful end-points in gene trials What should professional societies/organizations be doing to prepare for precision diagnostics and therapy in CVD?	Moderatored by the chairpersons
*10:45 - 11:00*	*Break*
11:00 - 11:45	Wrap-up from breakout groups – Call for actions? Key take-home messages and Recommendations in preparation of a publication	Chairpersons
12:00 – End of Day 2

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