HFA Winter Meeting on Translational Heart Failure Research

"The HFA Winter Meeting is the premier meeting for basic translational science in Europe, the excellence of which is recognised internationally. The organisers need to be congratulated on maintaining such uncompromising high standards over many years and for providing the young (and not-so-young) generation of scientists and clinician scientists with a fantastic opportunity to learn about the latest (unpublished) discoveries, participate to lively scholarly discussions, and network with the best scientists in the field. 

There is no doubt in my mind that HFA Winter Meeting is amongst the very best initiatives fostered by the ESC family and a model for future developments."

 

Prof. Barbara Casadei
ESC President 

Don't miss this offer

2019 HFA Winter Meeting

Winter is coming... Get ready for the next edition of the HFA Winter Meeting to be held in Switzerland from January 23-26, 2019.

The call for abstracts closed on 19 October. 

Watch this space to find out the winners of:

• Young Investigator Prizes (winner - €1,000; Runner-up - €400)
• Guido Tarone Award, the prize for highest ranking abstract overall (€1,500)

Registration fee: €220 (including local shuttle from/to Geneva Airport, free access to sessions, accommodation and food). 

 "Participating to the HFA Winter Meeting on Translational Heart Failure Research is a unique opportunity:

1. to develop a global networking by discussing our findings with Experts in the cardiovascular field.
2. to meet investigators from around the World presenting cutting-edge research on the latest advances in topics related to heart failure.
3. to gain visibility and feedback on our research. The size of the meeting allows experts in the field of cardiovascular research to see our work, and dedicated viewing times are planned for discussion with faculties and attendees. The poster sessions allow us to speak one-on-one with people interested in our research. Presenters benefit from this interaction by gaining feedback on projects.
4. to be recognized. Young researchers meeting certain criteria are eligible to participate in the Poster Award Competition.
5. to have your abstract selected for the Annual ESC-Heart Failure Conference and published in the European Journal of Heart Failure."

Delphine Mika, PhD
Signalisation & Physiopathologie Cardiovasculaire, Inserm Umr-S1180, Paris Sud

Find out more about presenting abstracts at the Winter Meeting by watching some videos of the 2018 YIA and Guido Tarone Award winners:

Programme 

Detailed  Programme

Thursday; January 24th

1. Welcome to the Winter Meeting
2. Gene editing and repair
   • Regulation of the fetal epicardial gene program via BRG1-SWI/SNF-dependent regulation of the Wt1.
   • Integrated CRISP-R cas9-based screening of coding and non-coding RNA for personalized medicine.
   • Mitochondrial DNA mutations in disease pathology.
   • Industry research perspective: latest technologies to study small and long non-coding RNAs.
3. Endothelial plasticity and function
   • Metabolic endothelial remodeling via Notch in the failing heart.
   • Endothelial plasticity in adult life: the flowers for a broken heart.
   • Resident macrophages regulate angiogenesis in the heart.
   • A molecular atlas of cell types and zonation in the brain vasculature.
4. Poster Session
   • YIA candidates are required to present in front of several judges.

Friday, January 25th

1. Myofilament interventions
   • Mechanosensing of myosin.
   • Metformin and neuregulin-1: how do they relax the failing heart?
   • RNA therapy for hypertrophic cardiomyopathy.
   • Industry/research perspective. Small molecules to alter sarcomere contractility – Stepping from mice to men.
2. Cancer and heart failure
   • DNA methylation-based immune response signature as diagnostic tool in disease.
   • Common immune pathways in heart failure and cancer.
   • T-cell mechanisms of CTLA-4 and PD-1 check point inhibitors causing cardiac damage.
   • The failing heart stimulates tumor growth
3. Novel methods & Brutsaert Lecture
   • Brutsaert Lecture: cardiac engineering, where do we stand?
   • CRISPR/Cas9 applications in heart failure.
   • Organ-on-a-chip systems integrating human retinal, cardiac and adipose tissue.

Saturday, January 26th

1. Chronobiology and aging
   • Metabolic induction of trained immunity through the mevalonate pathway.
   • Aged stem cells reprogram their daily rhythmic functions to adapt to stress.
   • Targeting cardiovascular senescence through senescence associated glycoprotein (SAGP).
   • Remodelin-mediated targeting of N-acetyltransferase 10 enhances healthspan.
2. Pulmonary hypertension & right heart failure
   • Pulmonary hypertension and right heart failure: what’s new?
   • Exosomes and microRNAs in endothelial cell function in pulmonary hypertension.
   • Reversibility of pulmonary hypertension and right heart failure.
   • Myeloperoxidase and rho-kinase involvement in right heart failure.
3. Closing session

You would like to know more about the quality content of HFA Winter Meeting? Watch hereunder some feedback made by 2018 faculties.

News from the 2018 HFA Winter Meeting

Talks were given by speakers with dedicated time for discussion. Participants number was limited to 120 attendees, which creates an atmosphere conducive to dialogue and networking.

Online programme

Meet the Faculty

Abstracts & presenters

What makes this meeting unique is a blend of cutting-edge basic science with state-of-the-art translational and clinical knowledge, aiming at further improving heart failure treatment.

All submitters of accepted abstracts were offered a free registration for Heart Failure Congress 2018 upon resubmission of their abstract.

Winter Meeting through the years

The HFA Winter Meeting on Translational Heart Failure Research has a long-standing tradition and has emerged as the best basic and translational heart failure meeting in Europe.  

The tradition started in 1983, initiated by Professor Dirk Brutsaert (Founding President of the Heart Failure Association of the ESC, 2004-2008), the first official meeting was chaired by Sir James Whyte Black, who developed the first b-blockers and was awarded the Nobel Prize for Physiology or Medicine in 1988.

Past editions

Guido Tarone Award

• 2018 - Maarten van den Hoogenhof (Amsterdam, NL) for "RBM20 mutations induce an arrhythmogenic dilated cardiomyopathy related to disturbed calcium handling".
• 2017 - Marco Mongillo (Padova, IT) for "Dynamics of neuro-effector coupling at cardiac sympathetic synapses".

Young investigator award

• Winners
• 2018 - Daniel Brayson (London, UK) for "Prelamin A toxicity drives 'inflammaging' of the myocardium: a mechanism for multiple cardiomyopathies".
• 2018 - Edoardo Bertero (Wurzburg, DE) for "Down regulation of the mitochondrial calcium uniporter hinders cardiac energy supply-and-demand matching in Barth syndrome".
• 2017 - Mahmoud Abdellatif (Graz, AT) for "The natural autophagy-inducer spermidine protects the aging heart and promotes longevity in mice".
• Runners up
• 2018 - Stephen Gray (London, UK) for "The mitochondrial unfolded protein response protects the heart during chronic pressure overload"
• 2017 - Ellen Dirkx (Trieste, IT) for "High throughput small molecules screen identifies the neuroactive alkaloid harmine as an inducer of cardiomyocyte proliferation".
• 2017 - Maxance Ribeiro (Paris, FR) for "New role of EPAC in the Anthracyclines-induced cardiotoxicity".

2018 rewarded abstract presenters with Prof. Rudolf de Boer (meeting coordinator) and Prof. Christoph Maack (chair of poster session jury).