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In this volume 11 of the Cardiovascular Genomics Insights, we discuss the role of genetics in the management of aortopathy patients, with the contribution of Professor Tristan Mirault (Georges-Pompidou European Hospital, Paris City University/ PARCC, Paris) and Doctor Gisela Teixido Haugaa (University Hospital, Vall D'Hebron, Spain). This content highlights the impact of the 2024 ESC Guidelines on aortic diseases on the care of patients, from the index case management, extending to the family members and the genetic counselling process.