Disturbed Sleep Supports Neutrophil Activation and Promotes Atherosclerosis and Plaque Necrosis

Many report insufficent sleep increasingly in the last decade. Sleep fragmentation seems to promote hypocretin-dependent myelopoiesis and atherogenesis, pointing to a neuroimmune link between sleep and atherosclerosis. This study demonstrates in mice models how sleep fragmentation affects neutrophil functions and plaque phenotype, which conditions plaque stability.