In order to bring you the best possible user experience, this site uses Javascript. If you are seeing this message, it is likely that the Javascript option in your browser is disabled. For optimal viewing of this site, please ensure that Javascript is enabled for your browser.
Did you know that your browser is out of date? To get the best experience using our website we recommend that you upgrade to a newer version. Learn more.

Can a personalised approach more accurately allocate cardiac devices?

Device Therapy
Ventricular Arrhythmias and Sudden Cardiac Death (SCD)

Sophia Antipolis – 25 April 2021:  A novel project testing the value of personalised treatment and applying artificial intelligence (AI) to better select patients for an implantable cardioverter defibrillator (ICD) is outlined today at EHRA 2021, the online annual congress of the ESC’s European Heart Rhythm Association (EHRA).1

Sudden cardiac death accounts for approximately one in five fatalities and is usually a consequence of myocardial infarction. ICD implantation is recommended to prevent sudden cardiac death in patients with reduced left ventricular ejection fraction (35% or lower).2

PROFID is an EU-funded project conducted by European cardiology leaders, including the ESC3 and coordinated by the Leipzig Heart Institute, Germany. Principal investigator Dr. Nikolaos Dagres said: “The current method of selecting patients for a defibrillator has substantial limitations. In absolute numbers, most sudden cardiac deaths occur in patients with moderately reduced or preserved ejection fraction (above 35%) yet they are left unprotected because they do not qualify for defibrillator implantation according to current guidelines.”

He continued: “In addition, as a result of better medical and interventional treatment of myocardial infarction, only a minority of patients who currently qualify for an ICD will ever require it yet may experience unintended shocks or complications associated with the device. Taken together, we clearly need to better select the patients who would benefit from this life-saving therapy.”

The project aims to personalise prevention of sudden cardiac death after myocardial infarction by developing a prediction model. Some 23 databases with several hundred thousand myocardial infarction patients from Europe, the US and Israel are being analysed using traditional statistical methods and AI to create a clinical prediction model for the individual risk of sudden cardiac death.

A defibrillator implantation strategy based on the predicted individual risk for sudden cardiac death will then be tested in two clinical trials including more than 3,900 patients in total. PROFID-Reduced will enrol patients with an ejection fraction of 35% or less but with a low predicted individual risk according to the model; they will be randomised to receive an ICD or not. PROFID-Preserved will include patients with an ejection fraction above 35% and a high predicted individual risk according to the model; they will be randomised to ICD versus no ICD.

“The goal is to reshape the decision making of defibrillator therapy so that those who need it get it, but those who do not need it do not,” said Dr. Dagres. “A study of the ethical aspects and of patients’ perspectives as well as a health economic analysis of the financial impact on healthcare systems will run alongside the trials.”

Today’s presentation will delve into the methodology for creating the prediction model and provide a status update. Dr. Dagres said: “PROFID’s ambition is to individualise the use of defibrillator therapy for the prevention of sudden cardiac death which will benefit patients and health systems.”



Notes to editor

ESC Press Office
Tel: +33 (0) 7 8531 2036

Follow us on Twitter @ESCardioNews 


PROFID has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 847999.


References and notes

1Session: “Cardiac arrest in Europe” on 25 April at 10:35 to 11:30 CEST.

2Priori SG, Blomström-Lundqvist C, Mazzanti A, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Europace. 2015;36:2793–2867.

3For more information on ESC EU-funded research projects visit:


About the European Heart Rhythm Association

The European Heart Rhythm Association (EHRA) is a branch of the European Society of Cardiology (ESC). Its aim is to improve patients’ quality of life and reduce sudden cardiac death by limiting the impact of heart rhythm disturbances. 

About the EHRA Congress  #EHRA2021

EHRA 2021 is the online annual congress of the European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC).

About the European Society of Cardiology

The ESC brings together health care professionals from more than 150 countries, working to advance cardiovascular medicine and help people to live longer, healthier lives.


Information for journalists about registration for EHRA 2021

EHRA 2021 takes place 23 to 25 April online.

  • Free registration applies only to accredited press.
  • Credentials: A valid press cardor appropriate letter of assignment with proof of three recent published articles (cardiology or health-related or referring to a previous ESC event). Read the ESC media and embargo policy.
  • The ESC Press Office will verify the documents and confirm by email that your press accreditation is valid.
  • The ESC Press Office decision is final regarding all press registration requests.