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N-cadherin overexpression enhances the reparative potency of human-induced pluripotent stem cell-derived cardiac myocytes in infarcted mouse hearts

Commented by the ESC WG on CARE

Basic Science - Cardiac Diseases - Ischemia, Infarction, Cardioprotection
ESC Working Groups

While it is true that we are still waiting for the final results of important clinical trials with reparative intention in patients with ST-segment elevation acute myocardial infarction, it appears clear that new regenerative and/or reparative products warrant further investigations. This is the case of this manuscript, which demonstrates that the manipulation of induced-pluripotent stem cell-derived cardiomyocytes to overexpress N-cadherin may improve the effectiveness of the cells in a murine model, in terms of cellular engraftment, left ventricular ejection fraction and infract size. The authors also further expand our mechanistic knowledge by identifying a cellular pathway (ERK) that appears to be linked to the higher survival of implanted cells and to the higher neo-vasculogenic capacity of the treatment.


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The content of this article reflects the personal opinion of the author/s and is not necessarily the official position of the European Society of Cardiology.

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