45th EWGCCE Meeting

  07:30 - 08:30 Live Abstract session
Chairpersons: E Passini (Oxford, GB) - KE Odening (Bern, CH)

Human-based computational and experimental investigation of disease mechanisms in mutation-specific hypertrophic cardiomyopathy
F Margara (Oxford,GB)

Development of a multiscale electromechanical computer model from cell to hemodynamics
A Lyon (Maastricht,NL)

Cholinergic regulation of cardiac pacemaker activity by L-type Cav1.3 channels
L Talssi (Montpellier,FR)

Functional characterization of drug responses in induced pluripotent stem cell-derived cardiomyocytes from a short QT syndrome type 5 patient
J Lee (Basel,CH)

Electro-mechanical and mechano-electrical interactions in healthy and drug-induced LQTS rabbit hearts
R Lewetag (Freiburg,DE)

Enhancing mutant IKS channel activity by increasing endogenous PIP2 levels and its interaction with PKA signalling pathway

Aminophylline affects the cardiac rat inward rectifier potassium current in a dual way
NJD Dourado Ramalho (Brno,CZ)

Beta-1 adrenergic receptors modulate pacemaker activity of mouse sino-atrial myocytes through L-type Cav1.3 channels
E Torre (Milan,IT)

  09:00 - 09:55 Neurohormonal disturbances and arrhythmias
Chairpersons: J Jalife (Ann Arbor, US) - L Sacconi (Sesto Fiorentino, IT)

09:00 The cardiac sympathetic network and cardiac electrical function
T Zaglia (Padova,IT)

09:12 Cardiomyocyte calcium signalling in cardiorenal syndrome
G Ruiz Hurtado (Alcorcon,ES)

09:24 CaMKII as a therapeutic target in catecholaminergic polymorphic ventricular tachycardia type 1
M Sadredini (Oslo,NO)

09:30 Glucagon-like peptide-1 directly increases heart rate and shortens atrial refractoriness: an in vivo and ex vivo study in pigs
AF Lubberding (Copenhagen N,DK)

09:36 Characterisation and modelling of the abnormal electrophysiological response under beta-adrenergic stimulation in hypertrophic cardiomyopathy
R Doste (Oxford,GB)

09:42 Neurohormonal disturbances and arrhythmias - discussion

  10:00 - 10:55 Structural microdomains in cardiomyocyte arrhythmogenesis 
Chairpersons: CA Remme (Amsterdam Z0, NL) - M Thomsen (Copenhagen, DK)

10:00 Dyadic plasticity in cardiomyocytes
W Louch (Oslo,NO)

10:12 Atrial t-tubule remodelling in heart failure
K Dibb (Manchester,GB)

10:24 When multiple caveolins make the difference: Cav1 partly compensates Cav3 alterations and rescues ion channels expression
P Benzoni (Milano,IT)

10:30 Desmosomal vulnerability renders left atria more susceptible to detrimental effects of androgenic anabolic steroids
LC Sommerfeld (Birmingham,GB)

10:36 OPN5 a new optogenetic receptor to study Gq signalling in the heart with light
A Wagdi (Goettingen,DE)

10:42 Structural microdomains in cardiomyocyte arrhythmogenesis - discussion

  11:00 - 11:55 Ion channel (dys)function
Chairpersons: M Bebarova (Brno, CZ) - DM Johnson (Milton Keynes, GB)

11:00 ORAI1- dependent intracellular calcium (dys)regulation
J Sabourin (Chatenay-Malabry,FR)

11:12 Ion-channel basis of circadian clock in the pacemaker
A D'souza (Manchester,GB)

11:24 The SCN5A point mutation M1875T, associated with familial atrial fibrillation, causes a gain-of-function effect of the cardiac Nav1.5 channel in atrial cardiomyocytes
M O'Reilly (Birmingham,GB)

11:30 Clinical, genetic and functional analysis of R562S-Kv7.1 mutation associated with long QT syndrome type 1
O Svecova (Brno,CZ)

11:36 Piezo1 and BKCa channels in human atrial fibroblasts: interplay and remodelling in atrial fibrillation
R Peyronnet (Freiburg,DE)

11:42 Ion channel (dys)function - discussion

  12:40 - 13:35 Carmeliet - Coraboeuf - Weidmann Lecture
Chairpersons: AM Gomez (Chatenay-Malabry Cedex, FR) - J Heijman (Maastricht, NL)

12:40 Repolarisation and electrical instability
A Zaza (Milan,IT)

13:30 Carmeliet - Coraboeuf - Weidmann lecture - discussion