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Transcriptional and epigenetic regulation of macrophages in atherosclerosis

Commented by Prof.dr. Menno P.J. de Winther

Basic Science - Cardiac Diseases - Leukocytes, Inflammation, Immunity
Genetics, Epigenetics, ncRNA

Kuznetsova T, Prange KHM, Glass CK, de Winther MPJ. Nat Rev Cardiol. 2019 Oct 2.PMID: 31578516  

Dysregulated macrophages are major drivers in cardio-metabolic diseases where local and systemic cues impact on the transcriptional programs of macrophages and their precursors, monocytes. In this review, the current understanding of the transcriptional and epigenetic regulation of monocytes and macrophages in relation to atherosclerotic disease is discussed, as is our increasing knowledge on the potential to interfere with these processes as therapeutic interventions.




Kuznetsova T, Prange KHM, Glass CK, de Winther MPJ. Nat Rev Cardiol. 2019 Oct 2. PMID: 31578516  

The content of this article reflects the personal opinion of the author/s and is not necessarily the official position of the European Society of Cardiology.

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