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The sound of silence... against vascular dysfunction

Commented by the ESC WG on Atherosclerosis and Vascular Biology

Vascular Biology and Physiology
Leukocytes, Inflammation, Immunity

Thanks to more and more research, the list of possible cardiovascular risk factors is increasing. Environmental stressors-like noise exposure is one of them, that is modifiable providing hope for prevention and treatment of cardiovascular diseases.

Molitor et al bring forward convincing evidence, in mice and in a translational cohort, that mechanistically links aircraft noise exposure to a systemic stress response with activation of myeloid cells, promoting adhesion and infiltration into cardiovascular tissue. Additionally pre-existing endothelial dysfunction induced by aircraft noise exposure aggravates ischaemic heart damage post myocardial infarction, driven by pro-inflammatory transcriptional changes in the vasculature. This pro-inflammatory vascular conditioning may also explain the further deterioration of chronic heart failure or acute coronary syndrome in response to environmental noise exposure.

This translational study is an elegant eye-opener for many, including health organizations and legal bodies who can save lives and decrease suffering at a population level.


Libby P. The changing landscape of atherosclerosis Commented by the ESC WG on Atherosclerosis and Vascular Biology - June Newsletter 2021.

Bäck M, Yurdagul A Jr, Tabas I, Öörni K, Kovanen PT. Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities. Nat Rev Cardiol. 2019;16:389-406.

Serhan CN. Pro-resolving lipid mediators are leads for resolution physiology. Nature. 2014;510:92-101


The content of this article reflects the personal opinion of the author/s and is not necessarily the official position of the European Society of Cardiology.

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