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Single-cell biology to move mountains in atherosclerosis

Commented by the ESC WG on Atherosclerosis and Vascular Biology

Atherosclerosis, Cerebrovascular Diseases, Aneurysm, Restenosis
Basic Science
Vascular Biology and Physiology
Leukocytes, Inflammation, Immunity

Atherosclerosis is the key disease process underlying cardiovascular death and disability. The pathogenesis of atherosclerosis is driven by multiple cell types present in the plaque, that all have different functions. Only now, with the arrival of advanced single cell transcriptomics, the cells present in the plaque can be mapped and studied in high detail. The nucleus of the working group for atherosclerosis and vascular biology of the ESC recently summarized the huge translational impact of these novel techniques, its opportunities and pitfalls, and how it can help us in the future research effort and novel clinical applications.

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de Winther MPJ, Bäck M, Evans P, Gomez D, Goncalves I, Jørgensen HF, Koenen RR, Lutgens E, Norata GD, Osto E, Dib L, Simons M, Stellos K, Ylä-Herttuala S, Winkels H, Bochaton-Piallat ML, Monaco C.
Eur Heart J. 2022 Dec 7:ehac686.

The content of this article reflects the personal opinion of the author/s and is not necessarily the official position of the European Society of Cardiology.

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