Knowing that the cellular transcriptional states in human atherosclerotic plaque composition allow the identification of targetable cells, this human study provides not only a high-resolution atlas of the immune cell landscape in plaques, but also focuses on myeloid subsets.
Most interestingly it identified a previously unknown subset of TLR-dependent PLIN2hi/TREM1hiinflammatory lipid-associated macrophages, whose signature is enriched in carotid plaques of patients with cerebrovascular events.
Read more here if you want to know more beyond generic immune-modulation. The future might rather require a potential selective targeting of deleterious macrophages subsets to avoid side effect when clinically implemented.
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