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Study reveals low adoption of advice to reduce nuclear cardiology radiation exposure

Vienna, Austria – 9 May 2017: A study in 65 countries has revealed low adoption of International Atomic Energy Agency recommendations to reduce nuclear cardiology radiation exposure. The research is presented today at ICNC 2017 by Dr Edward Hulten, a cardiologist at the Walter Reed National Military Medical Center, Bethesda, USA.1

Nuclear cardiology uses small amounts of radioactive tracers which are injected into the veins and taken up by the heart. A gamma camera images the radiation from the tracer. The cardiac images are used to measure the heart size and function, identify coronary heart disease, and predict the risk of a heart attack.

Dr Hulten said: “Nuclear cardiology is a key part of contemporary cardiology management and around 15 to 20 million procedures are performed annually. It gives information regarding diagnosis, prognosis, and the effects of therapeutic interventions.”

“Concerns have been raised about tests, including nuclear cardiology, that expose patients to ionising medical radiation,” he continued. “Medical radiation potentially raises the lifetime risk of cancer which is important for all patients, especially younger patients or when considering additional radiation over time from further medical studies.”

A goal of 9 mSv or less radiation exposure per scan was recommended by the American Society of Nuclear Cardiology (ASNC) in 2010. It was noted in a 2016 International Atomic Energy Agency (IAEA) nuclear cardiology guideline but not formally endorsed as a recommendation.2, 3

The IAEA developed eight quality metrics for responsible radiation use in nuclear cardiology: avoiding thallium 201 stress testing, avoiding dual isotope testing, avoiding too much technetium-99m and thallium 201, using stress only imaging, use of camera technologies to reduce dose, use of weight based dosing strategies for technetium-99m, and avoiding inappropriate dosing that can lead to “shine-through” artefacts.

The IAEA Nuclear Cardiology Protocols Study (INCAPS) assessed adherence to the eight quality metrics.  The present analysis investigated which metrics were most helpful in meeting the ASNC’s 9 mSv target. During one week in 2013, 308 nuclear cardiology laboratories were studied in 65 countries in Africa, Asia, Europe, Latin America, North America, and Oceania.

The survey included 7 911 nuclear cardiology scans. There was significant variability in adherence to the quality metrics across laboratories and regions. There was low adherence overall, with the majority of sites implementing less than half of the quality metrics.

When the researchers performed multivariable logistic regression analysis, they found that the practices most strongly associated with achieving a 9 mSv or less scan were the use of stress or rest only imaging, avoiding thallium, and use of camera technologies to reduce radiation dose.

Dr Hulten said: “When the 9 mSv recommendation was made in 2010 it was suggested that it should be achieved in 50% of scans by 2014. The INCAPS survey shows that there is still work to do. It is possible to reduce radiation exposure with existing techniques. Cadmium zinc telluride (CZT) cameras are more sensitive and allow for reduced dose scanning. With certain tracers you can achieve 1 mSv or less. But some scans use more than 30 mSv, so there is huge variability.”

Not every site has all of the hardware and technology, said Dr Hulten, so the first step is to look at what is possible within each lab. He said: “There are improvements every lab can make regardless of money – for example multiple position imaging, weight based dosing and stress only techniques. They do require adapting existing workflows which takes leadership but they should be feasible in most labs.”

He added: “Eventually cameras wear out and perhaps the decision on a replacement could factor in a reduced radiation dose which also lowers false positive tests and has the potential to reduce lab costs.”

Dr Hulten concluded: “The INCAPS survey is a crucial step towards improving patient care in the field of nuclear cardiology by quantifying worldwide adherence to best practices. Any test involving ionising radiation will increase cancers within a population but the risk must be weighed against the benefit of gaining information about heart disease. The 9 mSv goal is achievable, and the lower the better.”


Notes to editor

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Senior investigator: Dr Andrew Einstein, cardiologist, Columbia University, New York.
Regional coordinators: Nathan Better, Sallah Bouyousef, Henry Bom, Vikram Lele, V. Peter C. Magboo, Erick Alexanderson, Adel Allam, Mouaz Al-Mallah, Albert Flotats, Scott Jerome, Philipp Kaufmann, Osnat Luxemburg, Madan Rehani, Leslee Shaw, Richard Underwood, Susanna Wiener.

SOURCES OF FUNDING: IAEA, Magaret Q. Landenberger Research Foundation, Irving Scholars.

DISCLOSURES: Edward Hulten: None.  Andrew Einstein: research grants for other investigator-initiated studies from GE Healthcare, Philips Healthcare, and Spectrum Dynamics.

References and notes
1Dr Hulten will present the abstract ‘Odds of less than 9 mSv myocardial perfusion study in association with camera technology, reconstruction software, and acquisition protocols: from the IAEA nuclear cardiology protocols study (INCAPS)’ during the session Perfusion imaging methods and protocols, radiation exposure and other clinical general which takes place on 9 May from 10:00 to 11:00 in the Moderated Poster Area.
2Cerqueira MD, Allman KC, Ficaro EP, Hansen CL, Nichols KJ, Thompson RC, et al. Recommendations for reducing radiation exposure in myocardial perfusion imaging. J Nucl Cardiol. 2010;17:709–718.
3International Atomic Energy Agency. Nuclear Cardiology: Guidance on the Implementation of SPECT Myocardial Perfusion Imaging.  IAEA HUMAN HEALTH SERIES No. 23 (Rev. 1), IAEA, Vienna (2016).  
About the International Conference on Nuclear Cardiology and Cardiac CT (ICNC)
The International Conference on Nuclear Cardiology and Cardiac CT (ICNC) is held every two years and is organised in conjunction with the American Society of Nuclear Cardiology (ASNC), the European Association of Cardiovascular Imaging (EACVI) and the European Association of Nuclear Medicine (EANM).

About the European Association of Cardiovascular Imaging (EACVI)
The European Association of Cardiovascular Imaging (EACVI), a registered branch of the ESC, is the world leading network of Cardiovascular Imaging (CVI) experts, welcoming over 8 000 CVI professionals including cardiologists, sonographers, nurses, basic scientists and allied professionals.

About the European Society of Cardiology
The European Society of Cardiology brings together health care professionals from more than 140 countries, working to advance cardiovascular medicine and help people lead longer, healthier lives.

Information for journalists attending ICNC 2017
ICNC 2017 takes place 7 to 9 May 2017 in Vienna, Austria, at the Austria Centre Vienna. The full scientific programme is available here