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Our mission is to reduce the burden of cardiovascular disease through percutaneous cardiovascular interventions.
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Dr Ganghong Tian, senior author of the study, said: “During cardiac surgery fat tissue may need to be removed from patients to expose the heart. We were intrigued to find out whether this mediastinal fat, which would otherwise be discarded, contained stem cells that could be injected back into the heart before closing the chest. The idea was to improve heart function after a heart attack or heart failure.”
Dr Tian continued: “The beauty of using mediastinal adipose tissue is that there is no need for another surgical procedure. Our method converts useless tissue into a treatment. Using a patient’s own tissue avoids the possibility of their immune system rejecting the stem cells.”
Dr Tian said: “This is the first evidence that stem cells collected from the mediastinal fat region are cardioprotective. They displayed the same cardioprotective capacity we found in our previous research on stem cells from subcutaneous fat tissue. This raises the exciting possibility of using a patient’s own stem cells, isolated from waste tissue during cardiac surgery, to improve their heart function.”
He concluded: “Cardiac surgery aims to treat heart failure or restore normal blood flow to the heart. The major strength of our study is that we used waste tissue to isolate the patient’s own stem cells. Injecting these back into the patient while their chest is still open would essentially give them a double treatment during one procedure and improve their chances of recovery from ischaemic heart disease.”
Our mission: To reduce the burden of cardiovascular disease
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