Our mission is to become a worldwide reference for education in the field for all professionals involved in the process to disseminate knowledge & skills of Acute Cardiovascular Care.
Our mission is to promote excellence in clinical diagnosis, research, technical development, and education in cardiovascular imaging in Europe.
Our mission is to promote excellence in research, practice, education and policy in cardiovascular health, primary and secondary prevention.
Our mission is to reduce the burden of cardiovascular disease through percutaneous cardiovascular interventions.
Improving the quality of life and reducing sudden cardiac death by limiting the impact of heart rhythm disturbances.
Our mission is to improve quality of life and longevity, through better prevention, diagnosis and treatment of heart failure, including the establishment of networks for its management, education and research.
The ESC Working Groups' goal is to stimulate and disseminate scientific knowledge in different fields of cardiology.
The ESC Councils' goal is to share knowledge among medical professionals practising in specific cardiology domains.
Paris, France – Aug. 30, 2011: Results from the SCAAR study, presented at the ESC Congress 2011 today, showed that Percutaneous Coronary Intervention (PCI) with “new generation” Drug Eluting Stents, was associated with a 38% lower risk of clinically meaningful restenosis and a 50% lower risk of stent thrombosis compared to old generation DES.
Although many trials and studies support the overall early and mid-term safety and efficacy of first-generation drug-eluting stents, there has been concern on their long-term safety, especially regarding the potential risk of late stent thrombosis as well as late restenosis. New drug-eluting stents (n-DES) have been developed with the purpose of overcoming the current limitations of the older generation drug-eluting stents (o-DES).
The purpose of this study was to evaluate the long-term outcome in all patients who underwent stent implantation with bare metal stents (BMS), “older generation” drug eluting stents (o-DES), and “new generation” drug eluting stents (n-DES) in Sweden, using a national registry with complete consecutive enrolment, the Swedish Coronary Angiography and Angioplasty Registry (SCAAR).
The SCAAR holds data on consecutive patients from 29 centers that perform coronary angiography and percutaneous coronary intervention (PCI) in Sweden. The registry is sponsored by the Swedish Health Authorities and is independent of commercial funding. The technology is developed and administered by the Uppsala Clinical Research Center. Since 2001, SCAAR has been Internet-based, with recording of data online through an Internet interface in the catheterization laboratory; data are transferred in an encrypted format to a central server at the Uppsala Clinical Research Center.
All consecutive patients undergoing coronary angiography or PCI are included. Information with respect to restenosis and stent thrombosis has been registered for patients undergoing any subsequent coronary angiography for a clinical reason since the beginning of 2004.
Our study included 94384 stent implantations in Sweden (BMS, n=64631; o-DES, n= 19202; n-DES, n=10551), from November 2006 to October 2010. Follow-up was performed up to two years post-intervention.
The performance up to two years of different types n-DES was evaluated in an unselected large real-world population- including patients with myocardial infarction, three-vessel and/or left main disease, bifurcation lesions, graft disease, restenotic lesions and chronic total occlusions.
The main findings of this study are that PCI with “new generation” DES was associated with a 38% lower risk of clinically meaningful restenosis and a 50% lower risk of stent thrombosis compared to old generation DES. Further studies are needed in order to attempt to discriminate whether one of the three components of the new generation DES- the polymer, the stent alloy, the eluting-drug- is mainly involved in decreasing the incidence of stent thrombosis and restenosis.
Improved stent designs with thinner struts, more biocompatible polymers may have an important impact on drug elution profiles, endothelial coverage, and functional recovery.
In conclusion, we showed that patients treated with PCI with “new generation” DES have a considerably lower risk of restenosis and stent thrombosis at 2 years compared to older generation DES in a large real world population.
These findings can be useful for the management of patients with high risk profile that could benefit more from these new devices.
Contributors: Giovanna Sarno, MD, PhD, Bo Lagerqvist, MD, PhD, Stefan James, MD, PhD, on behalf of all SCAAR investigators.
This press release accompanies both a presentation and an ESC press conference at the ESC Congress 2011. Considerably lower risk of stent thrombosis and restenosis in "new generation" drug-eluting stents: a report from the nationwide complete Swedish Coronary Angiography and Angioplasty Registry (SCAAR) The press release has been written by the investigator and edited by the ESC and does not necessarily reflect the opinion of the European Society of Cardiology.
About the European Society of Cardiology The European Society of Cardiology (ESC) represents more than 68,000 cardiology professionals across Europe and the Mediterranean. Its mission is to reduce the burden of cardiovascular disease in Europe.
About ESC Congress 2011 ESC Congress 2011 will take place from 27 to 31 August at the Parc des Expositions - Paris Nord Villepinte, France. Information on the scientific programme is available here. More information on ESC Congress 2011 is available from the ESC Press Office or contact us at firstname.lastname@example.org
Our mission: To reduce the burden of cardiovascular disease
© 2017 European Society of Cardiology. All rights reserved