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Our mission is to improve quality of life and longevity, through better prevention, diagnosis and treatment of heart failure, including the establishment of networks for its management, education and research.
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Prof. José-Luis Zamorano
Ms Adriana Saltijeral
Prof. Leopoldo Perez de Isla,
Clinical evaluation and especially periodic echocardiographic assessment particularly are the cornerstones of the measurement of cardiac dysfunctions. Thus, measurements of left ventricular ejection fraction should be performed with using the same method during the complete follow-up. How frequently patients should be re-assessed following transient heart dysfunction and which patients are most at risk of adverse long-term outcomes remain unknown, although a clinical examination, EKG and echocardiography is always recomended before each cycle and every 4 – 12 weeks after the cycle an during the complete treatment.
Patients under chemotherapy treatment have an increased risk of developing cardiac toxicity. Until now, the main cardiac complications that have been described are left ventricular systolic dysfunction and heart failure. Continuous monitoring of a patient under this treatment is the best way to detect and establish an early diagnosis of cardiac toxicity. Echocardiography plays a definitive role for this assessment. (1)
Currently, the heart failure diagnosis of heart failure relies on clinical evaluation based on 1) history, 2) physical examination and 3) complementary tests. But heart failure symptoms are often non-specific. So, the use of adequate diagnostic methods to explore cardiac function is of critical importance in these patients.
The1) Eelectrocardiography should be routinely used to detect factors associated to with toxicity. Nevertheless, they these factors usually only appear only in advanced stages of the disease and their diagnostic accuracy is very limited. The 2) Eexercise stress testing is indicated in those patients with an intermediate pre-test probability of coronary artery disease and in those patients with doubts regarding a theirquestionable functional status. During and after treatment cessation of treatment, this test may be useful to accurately assess the functional status of a patient. The 3) Ccontinuous ambulatory electrocardiography is indicated when there is a need to clarify the diagnosis by detecting tachy or bradiarrythmias and in patients with sporadic symptoms to be related to arrhythmias such as syncope or palpitations. The Ttwenty-four-hours ambulatory blood pressure monitoring may be useful when considerable variability in the clinic measurement is found. 4) Electrophysiologic testing is recommended for in patients with previous myocardial infarction and symptoms suggestive of ventricular arrhythmias or left ventricular systolic dysfunction. 5) Tilt table testing is indicated in patients with unexplained syncope.
Echocardiography (Figure 1) is the cornerstone for of cardiac toxicity monitoring. Cardiac dysfunction is defined as a decrease in left ventricular ejection fraction of at least 10% to less than 55% or by a decrease of 5% in left ventricular ejection fraction in the presence of symptoms and signs of heart failure. Monitoring changes in left ventricular diastolic function could detect evidence of cardiotoxicity earlier than monitoring left ventricular ejection fraction. New methods based on Doppler-echocardiography such as tissue Doppler imaging and real-time 3D-echocardiography (Figure 2) are under evaluation. These techniques may enable more sensitive detection of early changes in myocardial function before those detected by traditional methods. (2,3,4)
Computed tomography-angiography may be useful in patients with intermediate probability of coronary artery disease specially if the electrocardiogram is not interpretable, if patient is unable to exercise or if the stress test provides equivocal results. The Ccardiac magnetic resonance may be used to evaluate left ventricular function prior to therapy and for monitoring the cardiac function during the cycles. Serial multi-gated blood pool imaging (MUGA) is very reproducible but has the cost of radiation exposure to a young population. (5)
Pulmonary artery catheterisation, coronary angiography and angiography of peripheral blood vessels, should be recommended only in cases of discrepancies among the results of the non-invasive tests or when more precise information is needed in order to optimisze the management of patients. Until now, very few little information regarding the possible role of biochemical markers is available. (6,7)
Table 1: Cardiac imaging tool to assess left ventricular systolic function and their principal advantages and pitfalls.
CT: cardiac computed tomography; CMR: cardiac magnetic resonance; MUGA: multigated blood pool imaging. Figure 1: Left ventricle M-mode echocardiography. Measurements of left ventricular end-diastolic diameter and end-systolic diameter are obtained and left ventricular ejection fraction is derived from them.
Figure 2: Real-time 3D echocardiography may play an interesting role in left ventricular function assessment. Their main advantages: global left ventricular assessment and improved accuracy. The content of this article reflects the personal opinion of the author/s and is not necessarily the official position of the European Society of Cardiology
1.Piccart-Gebhart MJ, Procter M, Leyland-Jones B, Goldhirsch A, Untch M, Smith I, Gianni L, Baselga J, Bell R, Jackisch C, Cameron D, Dowsett M, Barrios CH, Steger G, Huang CS, Andersson M, Inbar M, Lichinitser M, Lang I, Nitz U, Iwata H, Thomssen C, Lohrisch C, Suter TM, Ruschoff J, Suto T, Greatorex V, Ward C, Straehle C, McFadden E, Dolci MS, Gelber RD; Herceptin Adjuvant (HERA) Trial Study Team. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med. 2005 Oct 20;353 (16):1659-72. 2.1. Gutierrez-Chico JL, Zamorano JL, Pérez de Isla L, Orejas M, Almería C, Rodrigo JL, Ferreirós J, Serra V, Macaya C. Comparison of left ventricular volumen and ejection fraction measured by three-dimensional echocardiography and cardiac magnetic resonance in patients with various cardiomyopathies. Am J Cardiol. 2005 Mar 15;95(6):809-13. 3.2. Caiani EG, Corsi C, Zamorano J, Sugeng L, MacEneaney P, Weinert L, Battani R, Gutierrez JL, Koch R, Perez de Isla L, Mor-Avi V, Lang RM. Improved semiautomated quantification of left ventricular volumes and ejection fraction using 3-dimensional echocardiography with a full matrix-array transducer: comparison with magnetic resonance imaging. J Am Soc Echocardiogr. 2005 Aug;18(8):779-88. 4.3. Lee, BH, Goodenday, LS, Muswick, GJ, et al. Alterations in left ventricular diastolic function with doxorubicin therapy. J Am Coll Cardiol 1987; 9:184. 5.4. Hendel RC, Patel MR, Kramer CM, Poon M, Hendel RC, Carr JC, Gerstad NA, Gillam LD, Hodgson JM, Kim RJ, Kramer CM, Lesser JR, Martin ET, Messer JV, Redberg RF, Rubin GD, Rumsfeld JS, Taylor AJ, Weigold WG, Woodard PK, Brindis RG, Hendel RC, Douglas PS, Peterson ED, Wolk MJ, Allen JM, Patel MR; American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group; American College of Radiology; Society of Cardiovascular Computed Tomography; Society for Cardiovascular Magnetic Resonance; American Society of Nuclear Cardiology; North American Society for Cardiac Imaging; Society for Cardiovascular Angiography and Interventions; Society of Interventional Radiology. CCF/ACR/SCCT/SCMR/ASNC/NASCI/SCAI/SIR 2006 Appropriateness criteria for cardiac computed tomography and cardiac magnetic resonance imaging: a report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group, American College of Radiology, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, American Society of Nuclear Cardiology, North American Society for Cardiac Imaging, Society for Cardiovascular Angiography and Interventions, and Society of Interventional Radiology. J Am Coll Cardiol. 2006 Oct 3;48(7):1475-97. 6.5. Sparano JA, Brown DL, Wolff AC. Predicting cancer therapy-induced cardiotoxicity: the role of troponins and other markers. Drug Saf. 2002;25 (5):301-11. 7.Pichon MF, Cvitkovic F, Hacene K, Delaunay J, Lokiec F, Collignon MA, Pecking AP. Drug-induced cardiotoxicitystudied by longitudinal B-type natriuretic peptide assays and radionuclide ventriculography In Vivo. 2005 May-Jun;19(3):567-76.
Leopoldo Pérez de Isla, Adriana Saltijeral Cerezo and José Zamorano Instituto Cardiovascular Hospital Clínico San Carlos. Madrid. Spain
Correspondence: Leopoldo Pérez de Isla Unidad de Imagen Cardiovascular Hospital Clínico San Carlos Plaza Cristo Rey 28040-Madrid, Spain Tel: 0034913303290 Fax: 0034913303290 email@example.com
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