Our mission is to become a worldwide reference for education in the field for all professionals involved in the process to disseminate knowledge & skills of Acute Cardiovascular Care.
Our mission is to promote excellence in clinical diagnosis, research, technical development, and education in cardiovascular imaging in Europe.
Our mission is to promote excellence in research, practice, education and policy in cardiovascular health, primary and secondary prevention.
Our mission is to reduce the burden of cardiovascular disease in Europe through percutaneous cardiovascular interventions.
Our mission is to improve the quality of life of the population by reducing the impact of cardiac rhythm disturbances and reduce sudden cardiac death.
Our mission is to improve quality of life and longevity, through better prevention, diagnosis and treatment of heart failure, including the establishment of networks for its management, education and research.
The ESC Working Groups' goal is to stimulate and disseminate scientific knowledge in different fields of cardiology.
The ESC Councils' goal is to share knowledge among medical professionals practising in specific cardiology domains.
OUR MISSION: TO REDUCE THE BURDEN OF CARDIOVASCULAR DISEASE
Mr Yonathan Hasin
Prof. D Ghanim
The cerebrovascular and the cardiovascular systems are closely related. In neurologic conditions, there is a broad spectrum of cardiac manifestations including both mechanical and electrophysiological dysfunctions. The latter range from non-specific ECG changes to various rhythm disturbances including serious, life threatening, ventricular arrhythmias.
The main underlying mechanism of cardiac abnormalities in cerebrovascular (CV) disease is an abnormal autonomic nervous system function with altered sympathetic and parasympathetic output. The ECG abnormalities in CV diseases are ST elevation or depression, prolonged QT interval, T wave inversion and pathologic Q waves (1). Hypothalamic stimulation can reproduce the ECG changes that are seen in acute CV disease (2).
The rhythm disturbances that might be seen are torsade de pointes, and other life-threatening arrhythmias, atrial fibrillation, SVT and bradycardia due to sinoatrial block, sinus arrest and AV-Block (3). Other cardiac manifestations are neurogenic pulmonary edema, myocardial damage with cardiac enzymes and troponin elevation -at autopsy, subendocardial hemorrhage and fibrosis have been described.
Patients with subarachnoid hemorrhage suffering from life-threatening arrhythmia (VT/VF) have high concentrations of plasma catecholamine, serum CK-MB, myosin light chain and troponin T (4). Fifty percent of patients with subarachnoid hemorrhage have hypokalemia that can lead to arrhythmias.
The control sites of the autonomic function are the insular cortex, amygdala and the lateral hypothalamus. Patients with brain stem infarctions have higher mean plasma NE levels compared to patients with hemispheric infarctions. On the other hand, patients with hemispheric lesions have a higher incidence of cardiac arrhythmias compared to patients with brain stem infarction (5).
There is a cortical asymmetry in the regulation of cardiovascular functions. Animal studies demonstrated a higher sympathetic discharge in the right hemispheric stroke compared to left-sided strokes. Strokes in the region of the insula - especially the right one - are associated with a low heart rate variability and a high incidence of sudden death (6,7).
Other manifestations of insular involvement are nocturnal increases in blood pressure, high NE levels, QT prolongations and low sympathetic and parasympathetic activities (6,7).
High risk patients who need arrhythmia monitoring in the intensive care unit are those with insular involvement, right-sided stroke, advanced age, coexisting hypertensive or coronary heart disease and those expressing intense emotional stress (3).
Mental stress triggers ischemia in 40 to 70% of stable coronary patients with positive exercise tests. Mental stress induced ischemia is independently associated with a higher rate of fatal and nonfatal cardiac events. It predicts events over and above exercise-induced ischemia (8).
Another entity is transient LV apical ballooning (tako-tsubo-like left ventricular dysfunction) in the absence of CAD. It occurs predominantly in women after acute emotional or physical stress. The underlying etiology is not clear, but it can be myocardial stunning due to high level of catacholamines, coronary vasospasm, plaque ruptures, and myocarditis in genetically prone patients. The treatment is mainly beta blockers and the prognosis is good (9).
Systolic myocardial dysfunction - segmental or global - is seen in 42% of patients with brain death and it is not predicted by clinical, ECG or brain CT characteristics. Ventricular arrhythmias are more common (32% more) in patients with myocardial dysfunction (7). In spontaneous subarachnoid hemorrhages, there is a segmental myocardial dysfunction, but in head trauma there might be a segmental or global dysfunction.
The content of this article reflects the personal opinion of the author/s and is not necessarily the official position of the European Society of Cardiology.
1) Zaroff JG, Rordorf GA, et al:Cardiac outcome in patients with subarachnoid hemorrhage and electrocardiographic abnormalities. Neurosurg 44:34-9 ,1999. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9894961&query_hl=2&itool=pubmed_docsum
2) Poyee Tung, Alexander Kopelnik, et al. Predictors of Neurocardiogenic Injury After Subarachnoid Hemorrhage. Stroke, Feb 2004; 35: 548 - 551. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14739408&query_hl=19&itool=pubmed_docsum
3) Cheung RT, Hachinski V. The insula and cerebrogenic sudden death.Arch Neurol. 2000 Dec; 57(12):1685-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11115233&query_hl=21&itool=pubmed_docsum
4) Sato K, Masuda T, Izumi T. Subarachnoid hemorrhage and myocardial damage clinical and experimental studies. Jpn Heart J. 1999 Nov; 40(6):683-701. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10737553&query_hl=4&itool=pubmed_docsum
5) Cechetto DF, Hachinski V. Cardiovascular consequence of experimental stroke. Baillieres Clin Neurol. 1997 Jul; 6(2):297-308. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9483295&query_hl=17&itool=pubmed_docsum
6) Tokgozoglu SL, Batur MK, Top uoglu MA, Saribas O, Kes S, Oto A. Effects of stroke localization on cardiac autonomic balance and sudden death. Stroke. 1999 Jul; 30(7):1307-11. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10390300&query_hl=6&itool=pubmed_docsum
7) Furio Colivicchi, Andrea Bassi, et al. Cardiac Autonomic Derangement and Arrhythmias in Right-Sided Stroke With Insular Involvement. Stroke, Sep 2004; 35: 2094 - 2098. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15272134&query_hl=15&itool=pubmed_docsum
8) Krantz DS, Santiago HT, Kop WJ, Bairey Merz CN, Rozanski A, Gottdiener JS. Prognostic value of mental stress testing in coronary artery disease. Am J Cardiol. 1999 Dec 1; 84(11):1292-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10614793&query_hl=8&itool=pubmed_docsum
9) Wittstein I. S., Thiemann D. R., et al. Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress. N Engl J Med 2005; 352:539-548, Feb 10, 2005. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15703419&query_hl=10&itool=pubmed_docsum
10) Dujardin KS, McCully RB, et al. Myocardial dysfunction associated with brain death: clinical, echocardiographic, and pathologic features. J Heart Lung Transplant. 2001 Mar; 20(3):350-7. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11257562&query_hl=12&itool=pubmed_docsum
D. Ghanim & Y. Hasin The BARUCH PADEH Medical Center, Poriya, Israel
*Past-chairman of the ESC Working Group on Acute Cardiac Care
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