Dr. Anna F Dominiczak,
The session on a stratified approach to resistant hypertension brought together four excellent presentations, including Professor Roland Schmieder’s outstanding account of the diagnostic and therapeutic aspects of resistant hypertension in line with the new 2013 ESH/ESC Guidelines. This was followed by a clinical talk on management of resistant hypertension by Dr Adrian Brady, which included interesting case histories. The presentation on the role of metabolomics and genomics in delivering early interventions described new technological and bioinformatic advances in the area of polyomics, which although not yet ready for clinical practice, have been shown to discover new pathways and new mechanisms in cardiovascular disease.Last but not least, Professor Michel Azizi described exciting new inhibitors of the mineralocorticoid system. He demonstrated the mode of action and selectivity of the aldosterone synthase inhibitors (ASI) and showed very interesting data on non-steroidal antagonists of the mineralocorticoid receptor. The comparison between these compounds revealed that the latter group of compounds might be both superior and highly desirable in essential hypertension and perhaps also in early and potentially reversible primary aldosteronism.
Stratified approach to resistant hypertension
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