ESC Journals article - editor's choice
Ibrahim and Terracciano
The T-tubule system in ventricular cardiomyocytes is essential for synchronous Ca2+ handling, and, therefore, efficient contraction. T-tubular remodelling is a common feature of heart disease. In this review, we discuss whether t-tubular remodelling can be reversed and which factors may be implicated in this process. In particular, we focus on the interaction between mechanical load variation and T-tubule structure and function. What is the evidence of this relationship?... Read the free full article
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