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Sharing knowledge among medical professionals practising in specific cardiology domains

03/12/2010 00:00:00

ROS regulation of microdomain Ca2+ signalling at the dyads

ESC Journals article - editor's choice
Zhang, Gomez, Wang, Yan, Zheng and Cheng
Reactive oxygen species (ROS) are emerging as centre-stage players in cardiac functional regulation. ROS and Ca2+ signals converge at dyads, the structural and functional units of cardiac excitation–contraction coupling. These two prominent signalling systems are intertwined with ROS modulation of the entire Ca2+-signalling network, and vice versa. While constitutively generated homoeostatic ROS are important in setting the redox potential of the intracellular milieu, dynamic signalling ROS shape microdomain and global Ca2+ signals on both the beat-to-beat and greater time scales. However, ROS effects are complex and... Read the free full article

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The next EHRA certification exam for Allied Professionals will be held in Athens during EHRA EUROPACE on 23 June 2013.

Hurry, the registration deadline is fast approaching.
Register now to secure your place.

ESC supports European Commission's proposed Tobacco Products Directive

The ESC releases position paper on the European Commission's proposal for a directive on “the manufacture, presentation and sale of tobacco and related products”. Smoking is responsible for 25% of all avoidable deaths in smokers due to diseases of the heart and circulatory system or cardiovascular diseases (CVD).

Tricuspid valve: a valve not to be forgotten

Left side heart valve pathology often is accompanied by significant tricuspid regurgitation (TR) which does not always reverse with its correction. The new European guidelines recommend surgery on the tricuspid valve of these patients if TR is severe or provided the annulus is ≥40mm or ≥21mm/m², independently of the regurgitation. Thus, we are encouraged to act prophylactically in apparently less severe disease. Read more

ESC Councils

Basic Cardiovascular Science

Cardiology Practice

Cardiovascular Imaging

CV Nursing and Allied Professions

Cardiovascular Primary Care

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