ESC Journals article - editor's choice
Zhang, Gomez, Wang, Yan, Zheng and Cheng
Reactive oxygen species (ROS) are emerging as centre-stage players in cardiac functional regulation. ROS and Ca2+ signals converge at dyads, the structural and functional units of cardiac excitation–contraction coupling. These two prominent signalling systems are intertwined with ROS modulation of the entire Ca2+-signalling network, and vice versa. While constitutively generated homoeostatic ROS are important in setting the redox potential of the intracellular milieu, dynamic signalling ROS shape microdomain and global Ca2+ signals on both the beat-to-beat and greater time scales. However, ROS effects are complex and... Read the free full article
Discover Cardiovascular Research.