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Worse postoperative outcomes for critically ill patients bridged to urgent heart transplantation with VADs than with conventional therapy 

Results of Spanish National Heart Transplant Registry

Topics: Heart Failure (HF)
Date: 28 Aug 2011
Postoperative outcomes of severe heart failure patients bridged with short-term VADs to urgent ( status UNOS 1A) heart transplantation are significantly worse than those of patients bridged with conventional support, recent data of the Spanish National Heart Transplant Registry suggest.

Paris, France, 28 August:
Postoperative outcomes of severe heart failure patients bridged with short-term VADs to urgent ( status UNOS 1A) heart transplantation are significantly worse than those of patients bridged with conventional support, recent data of the Spanish National Heart Transplant Registry suggest.

Spanish investigators led by Drs. Eduardo Barge-Caballero and Marisa Crespo-Leiro from the Hospital Universitario A Coruña conducted a multi-institutional retrospective study of 704 patients with critical heart failure, who underwent urgent, high-priority heart transplantation in 15 Spanish hospitals from January, 2000 to December, 2009. One hundred and seven patients had been supported with short-term VADs before transplantation, while the remaining 597 had been bridged with conventional therapy, that included intravenous inotropes, invasive mechanical ventilation and / or intraaortic balloon pump. Implanted VADs were paracorporeal pulsatile-flow devices in 58 cases and extracorporeal continuous-flow ones in 47. Interestingly, mean waiting list time was extremely short, around 5 days, a characteristic fact of the well-organized Spanish high-emergency organ procurement and allocation system.

Despite fairly similar pre-transplant clinical status and end-organ function, VAD bridged patients showed a higher incidence of severe surgical bleeding, longer bypass times and higher rates of primary graft failure than conventionally bridged patients, so as resulting in a significantly reduced post-transplant survival.

In Dr. Barge-Caballero´s opinion, “our data suggest that routine short-term VAD implantation in stable patients awaiting high-emergency heart transplantation should not be recommended, at least in countries with expected short waiting list times, as this strategy might compromise heart transplant outcomes”. For the main investigator of the study, “short-term VAD support as a bridge to high-emergency heart transplantation should be reserved for critically ill patients with a deteriorating haemodynamic status, in which conventional therapy is not enough to ensure adequate peripheral perfusion and to avoid irreversible end-organ damage”.
 
Contributors: Drs. E. Barge-Caballero and M. Crespo-Leiro on behalf of the Spanish Group of Heart Transplant Teams.

Authors: Doctor Barge Caballero, Eduardo (A Coruna, Spain)

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Notes to editor

About the European Society of Cardiology
The European Society of Cardiology (ESC) represents more than 68,000 cardiology professionals across Europe and the Mediterranean. Its mission is to reduce the burden of cardiovascular disease in Europe.

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References This press release accompanies both a presentation and an ESC press conference at the ESC Congress 2011.

Comparison of postoperative outcomes of critically ill patients bridged to urgent heart transplantation with VADs or with conventional therapy: data from the spanish national heart transplant registry -  90638

The press release has been written by the investigator and edited by the ESC and does not necessarily reflect the opinion of the European Society of Cardiology.