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Angiotensin Converting Enzyme Inhibitors in Cardiovascular Disease (Expert Consensus Document on)

ESC Clinical Practice Guidelines

Heart Failure: Treatment
Cardiovascular Pharmacology and Pharmacotherapy
Guidelines version available to download
Published in 2004
Reference European Heart Journal (2004) 25, 1454–1470; doi:10.1016/j.ehj.2004.06.003
Table of contents: Full Text (ESC Clinical Practice Guidelines)


  • Definition
  • ACE-inhibitor classification
  • Pharmacokinetic profile
  • Mechanism of action
  • Effects of ACE-inhibitors: Haemodynamic effects, Neurohormonal effects, Antiproliferative effects, Renal effects, Other effects, Effects on fibrinolytic balance
  • Side effects
  • Contraindications
  • Drug interactions
  • Dosing

Clinical efficacy and practical use

  • Heart failure: Target dose, ACE-I compared with angiotensin, receptor blockers
  • Asymptomatic left ventricular systolic dysfunction, Diastolic failure
  • Acute myocardial infarction
  • Hypertension
  • Secondary prevention and high-risk of cardiovascular disease
  • Prevention of sudden cardiac death




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