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Optison Contrast agent additional details

An introduction to contrast echocardiography

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LICENCE FOR USE: Europe & United States
CONTENTS: Perflutren-containing microspheres (suspension of microspheres of heat-treated human albumin, suspended in 1% human albumin solution, containing perflutren gas)
STORAGE: Refrigerator (2-8°C)



OPTISON vials are stored in a refrigerator but should be allowed to settle at room temperature before use.

Click to enlarge the illustration about how to reconstitute OPTISON.


A) Bolus injection

  • 0.2ml of OPTISON is aspirated from the vial into a syringe
  • Inject contrast agent slowly followed by a 10ml saline flush
  • Ventricular opacification is noted within 5-10s of injection
  • Effective opacification usually persists for >60s
  • Repeated injections can be given if needed; patients can be given up to 3ml, over this volume is not recommended as clinical experience with higher doses is limited

B) Intravenous infusion

  • No specific infusion pump is available, although OPTISON can simply be dissolved in saline or glucose and infused using a standard intravenous giving set
  • The recommended dose is via an intravenous infusion of 1.3 ml added to 50 ml of 0.9% sodium chloride or 5% glucose solution for injection
  • The rate of infusion should be initiated at 4.0 ml/minute, but titrated as necessary to achieve optimal image enhancement, not to exceed 10 ml/minute