Our mission is to become a worldwide reference for education in the field for all professionals involved in the process to disseminate knowledge & skills of Acute Cardiovascular Care.
Our mission is to promote excellence in clinical diagnosis, research, technical development, and education in cardiovascular imaging in Europe.
Our mission is to promote excellence in research, practice, education and policy in cardiovascular health, primary and secondary prevention.
Our mission is to reduce the burden of cardiovascular disease through percutaneous cardiovascular interventions.
Improving the quality of life and reducing sudden cardiac death by limiting the impact of heart rhythm disturbances.
Our mission is to improve quality of life and longevity, through better prevention, diagnosis and treatment of heart failure, including the establishment of networks for its management, education and research.
The ESC Working Groups' goal is to stimulate and disseminate scientific knowledge in different fields of cardiology.
The ESC Councils' goal is to share knowledge among medical professionals practising in specific cardiology domains.
Mayyasa Rammah, Magali Théveniau-Ruissy, Francesca Rochais* and Robert G Kelly*
Aix-Marseille University, Developmental Biology Institute of Marseilles, CNRS UMR7288, 13288, Marseilles, France.*equal contribution
Cardiac progenitor cells of the second heart field (SHF) contribute to the poles of the elongating embryonic heart. Perturbation of SHF development leads to a spectrum of congenital heart defects. Recent evidence suggests that distinct regions of the heart are pre-patterned in the SHF. In particular, the myocardium at the base of the aorta and pulmonary trunk were shown to be prefigured in the outflow tract. For example the dell22q11.2 or DiGeorge syndrome gene Tbx1 is required in the SHF for development of the inferior wall of the embryonic outflow tract, giving rise to subpulmonary myocardium. By characterizing the expression of an enhancer trap transgene at the Hes1 locus, encoding a transcriptional repressor, we have identified a complementary Notch-dependent Hes1+ Tbx1- subpopulation of SHF cells giving rise to future subaortic myocardium. Using transcriptomic analysis on superior and inferior outflow tracts, we have characterized the distinct genetic signatures of future subaortic and subpulmonary myocardium and identified peroxisome proliferator activated receptor gamma (Pparg) among the genes enriched in future subpulmonary myocardium. We have also shown that Pparg acts as an upstream regulator in the cross-circuitry operating in superior and inferior OFT walls and plays a role in SHF cell addition to the OFT. Our genetic and explant analyses have revealed that Hes1, as a downstream target of Notch signaling pathway, controls the molecular signature of future subaortic myocardium through direct transcriptional repression of Pparg. Altogether, our study reveals distinct genetic regulatory networks controlling different progenitor cell contributions to the developing heart and identifies a crucial role of Hes1 in the regulation of cardiac progenitor cells fate.
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