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Working Group Talk "RNA-based therapies"

Live Online Event of the ESC Working Group on Cardiovascular Regenerative and Reparative Medicine

12/03/2024 15:30 12/03/2024 16:30 Europe/Paris Working Group Talk "RNA-based therapies"

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ESC Working Group on Cardiovascular Regenerative and Reparative Medicine DD/MM/YYYY
Pharmacology and Pharmacotherapy
ESC Working Groups


This live talk, chaired by Wolfram-Hubertus Zimmermann and Monika Gladka covers RNA-based therapies. John P. Cooke presents the limitless future of RNA therapeutics, while Kenneth Chien presents the unlocking of the promise of mRNA therapeutic.


Nucleotide and in particular RNA-therapeutics are of increasing importance. With Inclisiran (PMID: 27959715), we have the first small interfering RNA (siRNA) therapeutic for the blocking of PCSK9 translation in clinical practice for the lowing of LDL-cholesterol. More recently, CRISPR Cas9 encoding RNA with concomitant single guide RNA targeting misfolded transthyretin (TTR) has demonstrated clinical efficacy in patients with TTR amyloidosis (PMID: 34215024). Numerous RNA therapeutics will follow (PMID: 36329321; PMID: 33816449), riding also on the clinical experience gained from modRNA development for COVID vaccination, because they are easy to develop and can be precisely targeted as highly specific therapies.

Educational goals

  • Understand the basics of RNA-based advanced therapeutic medicinal products and their design and manufacturing
  • Be updated on current and future clinical-grade RNA-based therapies
  • Learn about potential applications and challenges for cardiovascular disease



Wolfram-Hubertus Zimmermann, DE



Monika Gladka, NL



The limitless future of RNA therapeutics 

John P. Cooke

John P. Cooke, USA



Unlocking the promise of mRNA therapeutic

Kenneth Chien, SE



Questions and Answers

During the Q&A, participants will have the opportunity to interact with the chairs and speaker by asking their questions verbally using the “Raise hand” feature or in written form using the "Q&A" module. Chairs and speakers can answer directly in the module (publicly or privately) or discuss live during the Q&A.


The registration is now close.

The event recording will be accessible on demand a couple of weeks after the live event.