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PhD student at University of Zurich-Department of Cardiology and Clinical Chemistry

At the University of Zurich, Switzerland, in the research group of Dr. Elena Osto, PhD, there is ONE open position for a PhD student to investigate the role of gut hormones in the control of endothelial cell function and metabolism in cardio-metabolic diseases

The project combines basic and clinical research. We work in close collaboration with ETH Zurich and the Veterinary Physiology at the University of Zurich.The dysfunction of endothelial cells is a key player in cardiovascular and metabolic disease. However, the molecular mechanisms that disrupt endothelial homeostasis remain unclear.We examine the crosstalk between gut hormones, adipose tissue, and the cardiovascular system in health and disease. The PhD’sfocus will be on circulating bile acids (BA)and their role in metabolism in a variety of tissues and cells, including the endothelium. Open questions: how BA cooperate with lipoprotein to regulate endothelial metabolism and function. In turn, it is unknown whether endothelial cells influence local and systemic metabolic processes via the control of BA trafficking, and signaling.Samples collected from animal model or patients with obesity, type 2 diabetes and after bariatric surgery or other types of weight loss treatments will be analyzed in parallel.This position requires a direct involvement in the experimental and clinical arms of the study and close interaction with other master and PhD students.

Start: march 2020

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