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Fellowship in Cardiac Electrophysiology Research (Large Animal Models)

Montreal Heart Institute Research Center

We are looking for MDs and/or PhDs for one or more fellowships in cardiac electrophysiology research, primarily in animal models. The laboratory studies mechanisms underlying cardiac arrhythmias, particularly atrial fibrillation, in a wide range of animal models including dogs, pigs, rats and mice.

We are particularly seeking fellows interested in working in large-animal models.The primary role of this fellow(s) will be to create the animal models and then to perform studies in vivo and in situ. The fellow will be involved at all stages of the research, including hypothesis generation, development of the research protocol, execution of the in vivo components, data acquisition and analysis, and preparation of the manuscript(s). All stages of the work will be performed under close supervision and cooperation with the lab director and other lab personnel. There will be opportunities for Abstract preparation and presentation at international meetings in cardiovascular physiology and electrophysiology.

The lab is a very rich research environment, using complementary methods including protein biochemistry, molecular biology, biophysics, cell biology and computer modeling. Professional staff resources are available for methodological support in optical mapping, biochemistry, imaging and cell physiology. All trainees in the lab interact and work cooperatively, and components of projects involving specialized in vitro and biochemical methods on specimens from large-animal models are performed by trainees or staff specialized in the area.

The principal research interest of the lab is in the development of novel mechanism-based approaches to treating arrhythmia syndromes. Methods used in large-animal model development and study include chronic instrumentation for pacing and recording, ablation methods for both model creation and study, Holter monitoring, in vivo electrophysiology including programmed stimulation and epicardial mapping, and optical mapping. Tissues are then harvested and processed for biochemistry, cell physiology, histochemistry and immunochemistry.

While the candidate(s) recruited for this position are not required to work in areas outside in vivo electrophysiology, they will have opportunities to learn and practice additional methods if desired, and certainly to collaborate with other staff and trainees using these methods.

While the possibility of attracting outside fellowship funding is an asset, internal funding is available to guarantee salary support for the position.

Remuneration is guaranteed at the scale of the local health research granting organization.

Candidates should have interest in in-vivo research and a background in clinical electrophysiology, in vivo physiology or pharmacology, or prior research experience and a desire to develop in vivo research skills. The position(s) are available for a minimum of 1 year, depending on experience, with the possibility of extension to a total of 5 years. Successful candidates will be able to assume the position any time between July 1 and December 31, 2018.

About Montreal Heart Institute Research Center

The Montreal Heart Institute is a free-standing teaching hospital focusing on heart disease prevention, diagnosis and treatment. It has a large and extremely active research center with extensive basic and clinical science research facilities and staff, and is a recognized world leader in cardiology research. Electrophysiology is one of 3 focus areas in both clinical and basic research. There is a rich scientific environment including seminars, clinical conferences, extensive common infrastructure/support in cardiac imaging, small-animal phenotyping, genetics, genomics, molecular biology and biostatistics. Specialized animal facilities are available for the creation, maintenance and study of cell and animal models from mice through dogs and pigs. These include facilities for animal fluoroscopy and angiography, electrophysiological and hemodynamic monitoring, the preparation, breeding and maintenance of transgenic animals, and gene transfer approaches.