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International Conference on Heart Failure with Preserved Ejection Fraction: Basic mechanisms

23-25 September 2011 in Budapest Hungary

Heart Failure (HF)

The scientific program included 15-20 poster presentations by young scientists following the abstract selection process. Abstracts concentrating on novel pathophysiological aspects of Heart Failure with Preserved Ejection Fraction, and based on original experimental and/or clinical observations would be appreciated.

Workshop programme

Friday 23 September
12:00 - 18:00 Arrival, Registration
18.00-18.20 Welcome address
Zoltán Papp, Burkert Pieske, Piotr Ponikowski
18.20-19.40 Session I: Ventriculo-Arterial coupling Chairs: Piotr Ponikowski, Paolo N. Marino, Stefan D. Anker
18.20-18.40 Ventricular properties and ventriculo-vascular coupling in an animal model of HFPEF and similarities/dys-similarities to observations in humans Daniel Burckhoff
18.40-19.00 The role of arterial stiffness and ventriculo-vascular coupling in HFPEF Vojtech Melenovsky
19.00-19.20 Asymmetry and dyssynchrony of ventriculo-arterial coupling - a target for treatment? Alan G. Fraser
19.20-19.40 Myocardial mechanics in diastole, and wall-motion - blood-flow interaction Jens-Uwe Voigt
Discussant Gilles De Keulenaer, Erwan Donal
Saturday 24 September
08.00-10.00 Session II: Myocardial function, cardiomyocytes and myofilaments Chairs: Burkert Pieske, Ger Stienen
08.00-8.20 Hypertrophic cardiomyopathy - a model for HFPEF Thomas Eschenhagen
08.20-8.40 Heterogeneity of cellular remodeling in ischemic cardiomyopathy Karin Sipido
08.40-9.00 Molecular mechanisms governing functional and structural changes in the pressure-overloaded human heart Stefan Janssens
09.00-9.20 Cardiomyocyte dysfunction in HFPEF: the role of myofilament protein alterations Attila Borbély
09.20-9.40 Phosphorylation of titin as an important determinant of myocardial passive stiffness Wolfgang Linke
09.40-10.00 Mechanisms of LV lengthening velocity - is it only about diastolic function? Otto Smiseth
Discussants Franck Rademakers
10.00-10.20 Break

10.20-12.20 Session III: Neurohumoral signaling Chairs: Andrew Coats, Heikki Ruskoaho
10.20-10.40 Acute neurohumoral modulation of diastolic function Adelino Leite-Moreira
10.40-11.00 Paracrine regulators in diastolic dysfunction István Szokodi
11.00-11.20 Cell-specific role of NADPH oxidases in diastolic dysfunction Ajay Shah
11.20-11.40 Mitochondrial redox regulation and myocardial remodelling Cristoph Maack
11.40-12.00 Low myocardial protein kinase G activity in HFPEF: causes and consequences Walter Paulus
12.00-12.20 Pro-hypertrophic signaling and diastolic dysfunction Leon De Windt
Discussants Rodolphe Fischmeister, Michael Fu

12.20-14.00 Lunch

14.00-16.00 Session IV: Exercise testing and clinical data Chair: Dirk Brutsaert, Alan G. Fraser
14.00-14.20 Cardiovascular reserve function with exercise in HFPEF Barry Borlaug
14.20-14.40 The role of invasive exercise hemodynamics in the diagnosis of HFPEF David Kaye
14.40-15.00 Effects of exercise training on cardiac remodeling and dysfunction: Importance of the underlying pathology Dirk J. Duncker
15.00-15.20 HFPEF in the Heart Failure Pilot Survey (ESC-HF Pilot) Aldo Maggioni
Discussants Walter Paulus, Franck Flachskampf
15.20-16.00 Break

16.00-17.40 Session V: Extracellular matrix Chair: Javier Díez, Gerasimos Filippatos
16.00-16.20 Inflammation and matrix regulation in HFPEF Carsten Tschöpe
16.20-16.40 Biomarkers of extracellular matrix turnover in LVH and HFPEF Faiez Zannad
16.40-17.00 Collagen and new biomarkers Kenneth McDonald
17.00-17.20 The matricellular proteins osteoglycin and osteonectin regulate matrix maturation and cardiac function Stephane Heymans Looking for new therapeutic targets of myocardial fibrosis in HFPEF. From the bench to the bedside Javier Diez
Discussants Michael Frenneaux, Dirk J. Duncker
18.00-20.00 "MEDIA" Discussion / Posters

Sunday 25th September
08.00-10.00 Sesssion VI: New directions Chair: Carsten Tschöpe, Ajay Shah
08.00-08.20 Diastolic dysfunction in diabetes mellitus: The dawn of cardiometabolic continuum Petar Seferovic
08.20-08.40 Salvaging the diabetic heart with endothelial factors Giles de Keulenaer
08.40-09.00 Pulmonary hypertension in HFPEF Marco Guazzi
09.00-09.20 Revealing diastolic dysfunction in mice, a lesson from MRI in vivo Stefan Chlopicki
09.20-09.40 Exercise-induced diastolic and systolic dysfunction in HFPEF – mechanisms and implications Michael Frenneaux
Discussants Thomas Eschenhagen, Ludwig Neyses
10.00-10.10 Break

10.10-12.40 Session VII: Therapy Chair: Walter Paulus, Faiez Zannad
10:10-10:30 Beta blockers in HFPEF Andrew Coats
10.30-10.50 HFPEF and stem cells Fida Grynspan
10.50-11.10 Cell therapy for the failing heart: from gene to protein Stephane Heymans
11.10-11.30 Exercise as therapeutic intervention in HFPEF Burkert Pieske
11.30-11.50 Meta-analysis on medical therapy Thomas H. Marwick
11.50-12.10 Why have HFPEF clinical trials failed so far? Scott Solomon
Discussants Stefan Chlopicki and Burkert Pieske
12:30-12.40 Summary and Conclusions Burkert Pieske, Zoltán Papp