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VentHeft is a multi-centre trial aiming to investigate the additive effects of inspiratory muscle training (IMT) on whole-body endurance training cardiac rehabilitation programs for chronic heart failure patients. Two groups of patients will be studied: in Group I patients will participate in a standard whole-body endurance training program while in Group II a supervised IMT will be added to standard whole-body endurance training programme
Study Protocol: Randomized multi-centre trialPatient Population: No of patients: at least 6-8 per group (per centre) Stable chronic heart failure, NYHA: II-III-IV, LVEF<35%
Group I: Endurance training programme (12 weeks) Treadmill/bike Intensity: 60-80% max heart rate (or, better, VO2max if possible) for 45 minutesFrequency: 3-5/week
Group II: Endurance training programme + IMT (12 weeks)Treadmill/bikeIntensity: 60-80% max heart rate (or, better, VO2max if possible) for 45 minutesFrequency: 3-5/weekDevice for IMT: computerised system/electronic pressure manometer -TRAINAIRIntensity: 60% of sustained maximal inspiratory pressure (SPimax) to exhaustionFrequency: 3-5/week
Measurements (pre and post-training)Inspiratory muscle strength (Pimax) and inspiratory work capacity (SPimax) (TRAINAIR )Ergospirometry (peakVO2) and/or 6-min walk test (according to ATS guidelines 2002)Dyspnea (Borg scale 0-10) at the end of exercise testingQuality of Life (Minnesota Living with Heart Failure Questionnaire)EchocardiographySpirometryBlood sampling(It is advisable to re-evaluate patients 1 year after the completion of training for mortality and morbidity records)Do you wish to participate in this interesting multi-centre trial? Contact us!
Principal investigators Stamatis Adamopoulos emailMiguel Mendes emailHugo Saner email
Study coordinator Ioannis Laoutaris email
Coordinating Centre Onassis Cardiac Surgery Center356 Sygrou Av.,176 74, Athens, GreeceTel: 0030 210 9493000-9493184Fax: 0030 213 9493186
Our mission: To reduce the burden of cardiovascular disease
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