Our mission is to become a worldwide reference for education in the field for all professionals involved in the process to disseminate knowledge & skills of Acute Cardiovascular Care.
Our mission is to promote excellence in clinical diagnosis, research, technical development, and education in cardiovascular imaging in Europe.
Our mission is to promote excellence in research, practice, education and policy in cardiovascular health, primary and secondary prevention.
Our mission is to reduce the burden of cardiovascular disease through percutaneous cardiovascular interventions.
Improving the quality of life and reducing sudden cardiac death by limiting the impact of heart rhythm disturbances.
Our mission is to improve quality of life and longevity, through better prevention, diagnosis and treatment of heart failure, including the establishment of networks for its management, education and research.
The ESC Working Groups' goal is to stimulate and disseminate scientific knowledge in different fields of cardiology.
The ESC Councils' goal is to share knowledge among medical professionals practising in specific cardiology domains.
OUR MISSION: TO REDUCE THE BURDEN OF CARDIOVASCULAR DISEASE
Dr. Paul Leeson,
High Fat Intake Leads to Acute Postprandial Exposure to Circulating Endotoxin in Type 2 Diabetic Subjects A. L. Harte et al. Diabetes Care 2011; Advance online publication
Recent studies by a research group in Warwick, UK have explored whether dietary patterns in diabetics might drive a persistent inflammatory response relevant to the development of vascular disease. A paper by Harte et al. looked at factors that are released into the circulation following a high fat meal. They were particularly interested in ‘endotoxin’, the lipopolysaccharide outer cell membrane of gram-negative gut bacteria, which is released from the gut into the portal circulation and can then be identified in the systemic circulation. The substance has been known about for over 30 years and is thought to induce an innate immune inflammatory response particularly in adipose tissue. In the current paper they looked at circulating levels following a high fat meal in those with Type 2 diabetes, impaired glucose tolerance and normals. They found higher levels in all subjects by one hour after the meal but substantially greater rises in those with Type 2 diabetes up to 4 hours later. They argue that repeated small meals may therefore lead to chronic elevation of endotoxin levels in those with Type 2 diabetes and a subsequent chronic inflammatory state. This is one of several possible mechanisms linking dietary patterns in Type 2 diabetes with subsequent cardiovascular risks and further experimental studies will be of interest to understand fully its importance as a disease mechanism.
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