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Basic Science Section: TranslatE Study


The EACPR Basic Science Section decided to concentrate on the investigation of moderate training vs. interval training and is generating a study-proposal titled: Optimizing exercise training for cardiovascular regeneration and reverse remodelling in heart failure. The acronym for the study will be “translatE”.

Under this study the following sub-projects are planned

  • Importance of oxidative stress – investigation of transgenic animal models like NADPH KO mice and katalase transgenic mice
  • Tissue derived cardiac stem cells – investigation of animal models analyzing the influence of different training modalities on the amount, distribution and function of tissue stem cells
  • Endothelial progenitor cells (EPCs) and vascular function. This will be the clinical part of the proposal
  • Myocardial function and calcium handling in the myocardium. These investigations will be performed in animal models and cell culture
  • Anabolic / catabolic enzymes in the skeletal muscle. These investigations may be performed in tissue material from animals as well as muscle biopsies obtained from patients
  • Mitochondrial function and biogenesis. Performed in tissue material from animals and may be patients
  • Proteomics

Learn more about the Basic Science Section
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