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In this issue of the ESC Virtual Journal, we celebrate the upcoming Heart Failure 2017 meeting in Paris from 29th April to 2nd May. Our guest editor, Professor Scott Solomon, has highlighted a selection of the must-see articles on Heart Failure from across the ESC Journal Family.We have made these free to view in full-text format, so you can fully benefit from the science we publish.
Palliative care in heart failure: a position statement from the palliative care workshop of the Heart Failure Association of the European Society of CardiologyTiny Jaarsma*, James M. Beattie, Mary Ryder, Frans H. Rutten, Theresa McDonagh, Paul Mohacsi, Scott A. Murray, Thomas Grodzicki, Ingrid Bergh, Marco Metra, Inger Ekman, Christiane Angermann, Marcia Leventhal, Antonis Pitsis, Stefan D. Anker, Antonello Gavazzi, Piotr Ponikowski, Kenneth Dickstein, Etienne Delacretaz, Lynda Blue, Florian Strasser, and John McMurray on behalf of the Advanced Heart Failure Study Group of the HFA of the ESC
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Frequent coexistence of chronic heart failure and chronic obstructive pulmonary disease in respiratory and cardiac outpatients: Evidence from SUSPIRIUM, a multicentre Italian surveyGriffo R, Spanevello A, Temporelli PL, Faggiano P, Carone M, Magni G, Ambrosino N, Tavazzi L and SUSPIRIUM Investigators.
Iron-regulatory proteins secure iron availability in cardiomyocytes to prevent heart failureSaba Haddad, Yong Wang, Bruno Galy, Mortimer Korf-Klingebiel, Valentin Hirsch,Abdul M. Baru, Fatemeh Rostami, Marc R. Reboll, Jörg Heineke, Ulrich Flögel,Stephanie Groos, André Renner, Karl Toischer, Fabian Zimmermann, Stefan Engeli, Jens Jordan, Johann Bauersachs, Matthias W. Hentze, Kai C. Wollert, Tibor Kempf
A landscape of circular RNA expression in the human heartCardiovasc Res (2017) 113 (3): 298-309.Wilson L. W. Tan, Benson T. S. Lim, Chukwuemeka G. O. Anene-Nzelu, Matthew Ackers-Johnson, Albert Dashi, Kelvin See, Zenia Tiang, Dominic Paul Lee, Wee Woon Chua, Tuan D. A. Luu, Peter Y. Q. Li, Arthur Mark Richards, Roger S. Y. Foo
A landscape of circular RNA expression in the human heartWilson L. W. Tan et al ; Cardiovasc Res (2017) 113 (3): 298-309.
Influenza vaccination and risk of hospitalization in patients with heart failure: a self-controlled case series study Hamid Mohseni, Amit Kiran, Reza Khorshidi, Kazem Rahimi; Eur Heart J (2017) 38 (5): 326-333
Iron-regulatory proteins secure iron availability in cardiomyocytes to prevent heart failureSaba Haddad, Yong Wang, Bruno Galy, Mortimer Korf-Klingebiel, Valentin Hirsch; Eur Heart J (2017) 38 (5): 362-372
Regional and ethnic differences among patients with heart failure in Asia: the Asian sudden cardiac death in heart failure registry Carolyn S.P. Lam, Tiew-Hwa Katherine Teng, Wan Ting Tay, Inder Anand, Shu Zhang; Eur Heart J (2016) 37 (41): 3141-3153.
Genomic correction of familial cardiomyopathy in human engineered cardiac tissuesFrancesca Stillitano, Irene C. Turnbull, Ioannis Karakikes, Mathieu Nonnenmacher, Peter Backeris; Eur Heart J (2016) 37 (43): 3282-3284.
Abnormal right ventricular-pulmonary artery coupling with exercise in heart failure with preserved ejection fractionBarry A. Borlaug, Garvan C. Kane, Vojtech Melenovsky, Thomas P. Olson; Eur Heart J (2016) 37 (43): 3293-3302
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC Piotr Ponikowski, Authors/Task Force Members, Adriaan A. Voors, Authors/Task Force Members, Stefan D. Anker; Eur Heart J (2016) 37 (27): 2129-2200
A randomized controlled study of finerenone vs. eplerenone in patients with worsening chronic heart failure and diabetes mellitus and/or chronic kidney diseaseGerasimos Filippatos, Stefan D. Anker, Michael Böhm, Mihai Gheorghiade, Lars Køber; Eur Heart J (2016) 37 (27): 2105-2114
Risk factors for heart failure are associated with alterations of the LV end- diastolic pressure–volume relationship in non-heart failure individuals: data from a large-scale, population-based cohort Michael Schwarzl, Francisco Ojeda, Tanja Zeller, Moritz Seiffert, Peter M. Becher ; Eur Heart J (2016) 37 (23): 1807-1814.
Fluid status telemedicine alerts for heart failure: a randomized controlled trial Michael Böhm, Helmut Drexler, Hanno Oswald, Karin Rybak, Ralph Bosch; Eur Heart J (2016) 37 (41): 3154-3163.
Current management of patients with severe acute peripartum cardiomyopathy: practical guidance from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathyJohann Bauersachs et al; DOI: 10.1002/ejhf.586
Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensinâ€converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trialMcMurray John J. V et al; DOI: 10.1093/eurjhf/hft052
Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double-blind, randomized comparison of two uptitration regimensMichele Senni et al; DOI: 10.1002/ejhf.548
Palliative care in heart failure: a position statement from the palliative care workshop of the Heart Failure Association of the European Society of CardiologyJaarsma Tiny et al; DOI: 10.1093/eurjhf/hfp041
Efficacy of sacubitril/valsartan vs. enalapril at lower than target doses in heart failure with reduced ejection fraction: the PARADIGM-HF trialOrly Vardeny et al; DOI: 10.1002/ejhf.580
Heart failure outcomes in clinical trials of glucose-lowering agents in patients with diabetesDavid H. Fitchett et al; DOI: 10.1002/ejhf.633
Diagnosis and management of aortic valve stenosis in patients with heart failureVasileios Kamperidis et al; DOI: 10.1002/ejhf.466
Effects of yoga versus hydrotherapy training on health-related quality of life and exercise capacity in patients with heart failure: A randomized controlled studyHägglund E, Hagerman I, Dencker K, Strömberg A; Eur J CV Nursing DOI: 10.1177/1474515117690297
Sexuality of patients with chronic heart failure and their spouses and the need for information regarding sexuality. Driel AG, de Hosson MJ, Gamel C; Eur J CV Nursing DOI: 10.1177/1474515113485521
Frequent coexistence of chronic heart failure and chronic obstructive pulmonary disease in respiratory and cardiac outpatients: Evidence from SUSPIRIUM, a multicentre Italian survey Griffo R, Spanevello A, Temporelli PL, Faggiano P, Carone M, Magni G, Ambrosino N, Tavazzi L; SUSPIRIUM Investigators; Eur J Prev Cardiol 24 (6), 567-576. 2017 Jan 09
Acute effects of Finnish sauna and cold-water immersion on haemodynamic variables and autonomic nervous system activity in patients with heart failureRadtke T, Poerschke D, Wilhelm M, Trachsel LD, Tschanz H, Matter F, Jauslin D, Saner H, Schmid JP; Eur J Prev Cardiol. 2016 Apr;23(6):593-601.
#1 Heart failure is a serious condition and equivalent to malignant disease in terms of symptom burden and mortality. At this moment only a comparatively small number of heart failure patients receive specialist palliative care. Heart failure patients may have generic palliative care needs, such as refractory multifaceted symptoms, communication and decision making issues and the requirement for family support. The Advanced Heart Failure Study Group of the Heart Failure Association of the European Society of Cardiology organised a workshop to address the issue of palliative care in heart failure to increase awareness of the need for palliative care. Additional objectives included improving the accessibility and quality of palliative care for heart failure patients and promoting the development of heart failure-orientated palliative care services across Europe. This document represents a synthesis of the presentations and discussion during the workshop and describes recommendations in the area of delivery of quality care to patients and families, education, treatment coordination, research and policy. Back to top
#2 Chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) frequently coexist but concurrent COPD + CHF has been little investigated.This multicentre survey (SUSPIRIUM) was designed to evaluate: the prevalence of COPD in stable CHF and CHF in stable COPD; diagnostic/therapeutic workup for concurrent COPD + CHF; a clinical profile of patients with COPD + CHF; predictors of COPD in CHF and CHF in COPD. Back to top
#3 Iron deficiency (ID) is associated with adverse outcomes in heart failure (HF) but the underlying mechanisms are incompletely understood. Intracellular iron availability is secured by two mRNA-binding iron-regulatory proteins (IRPs), IRP1 and IRP2. We generated mice with a cardiomyocyte-targeted deletion of Irp1 and Irp2 to explore the functional implications of ID in the heart independent of systemic ID and anaemia. Back to top
#4 Circular RNA (circRNA) is a newly validated class of single-stranded RNA, ubiquitously expressed in mammalian tissues and possessing key functions including acting as microRNA sponges and as transcriptional regulators by binding to RNA-binding proteins. While independent studies confirm the expression of circRNA in various tissue types, genome-wide circRNA expression in the heart has yet to be described in detail. Back to top
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