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Monthly Scientific Review

Monthly scientific review of interesting papers in Nuclear Cardiology and Cardiac CT

This selection of scientific papers is provided to you by Dr. J. De Sutter, MD, PhD, Prof. S. Schroeder and Dr M. Zellweger, MD, respectively.
Read the abstracts of those reports below and discover the full articles by clicking on their headlines in the following list (PDF Documents). 

From September 2007 there will be two monthly reviews: one rather focussing on cardiac CT, one on nuclear cardiology.

We wish you a pleasant read!


Monthly Reviews 2009


 Prognostic Value of Multidetector Coronary Computed Tomographic Angiography for Prediction of All-Cause Mortality


 Cardiac Dual-Source Computed Tomography;
effect of Body Mass Index on Image Quality and Diagnostic Accuracy
Diagnostic Performance of 64-Multidetector Row Coronary Computed Tomographic Angiography for Evaluation of Coronary Artery Stenosis in Individuals Without Known Coronary Artery Disease Results From the Prospective Multicenter ACCURACY


Monthly Reviews 2008


 Diagnostic Performance of Coronary Angiography by 64-Row CT Diagnostic Performance of 64-Multidetector Row Coronary Computed Tomographic Angiography for Evaluation of Coronary Artery Stenosis in Individuals Without Known Coronary Artery Disease Results From the Prospective Multicenter ACCURACY

 Perfusion SPECT and the impact of renal function on cardiac death


 Diagnostic Performance of 64-Multidetector Row Coronary Computed Tomographic Angiography for Evaluation of Coronary Artery Stenosis in Individuals Without Known Coronary Artery Disease Results From the Prospective Multicenter ACCURACY

 High dose adenosine overcomes the attenuation of myocardial perfusion reserve caused by caffeine 


 Dual-Source CT in Step-and-Shoot Mode: Noninvasive Coronary Angiography with Low Radiation Dose

 Radiopharmaceutical agents for myocardial perfusion imaging


 Effect of trimetazidin, a metabolic modulator, in idiopathic dilated cardiomyopathy  


 The effects of medications on myocardial perfusion


 Accuracy of Dual-Source computed tomography in the assessment of plaque morphology: use of quantitative plaque analysis software in comparison to IVUS virtual histology



 Noninvasive Evaluation of the Aortic Root with Multi-Slice Computed Tomography - Implications for transcatheter aortic valve replacement 

Percutaneous transcatheter aortic valve replacement has emerged as a novel procedure in the treatment of aortic stenosis. How can cardiac CT be used in patients who are planned for this procedure?


 Application of Appropriateness Criteria to Stress Single-Photon Emission Computed Tomography Sestamibi Studies and Stress Echocardiograms in an Academic Medical Center 


 Quantification of Coronary Plaque by 64-slice Computed Tomography: A Comparison with Quantitative Intracoronary Ultrasound 

Read in which patients plaque characterization is possible with cardiac CT.

  New position statement on myocardial perfusion scintigraphy 

The new position statement updates information regarding myocardial perfusion imaging and is a useful addition to the published guidelines.


Interrelation of Coronary Calcification, Myocardial Ischemia, and Outcomes in Patients With Intermediate Likelihood of Coronary Artery Disease 

Read about prognostic value of calcium score, perfusion by PET and their interrelation regarding prognosis

Annexin V scintigraphy and imaging of endocarditis

Annexin V imaging potentially provides a new imaging tool for the diagnosis of endocarditis


Prognostic Value of Number and Site of Calcified coronary Lesions Compared with the Total Score 

The mortality rate is increasing proportionally to the number of calcified lesions

Prediction of Cardiac Death in Hemodialysis Patients by Myocardial Fatty Acid Imaging 

Risk assessment by fatty acid imaging in patients with end stage renal disease - a method to identify repetetive myocardial ischemia?


 Feasibility of low-dose coronary CT angiography: first experience with prospective ECG gating 

This paper provides information about techniques that allow to save radiation exposure.

Differential improvement in stress myocardial perfusion ischemia following percutaneous coronary intervention as compared with optimal medical therapy alone: nuclear substudy results from the clinical outcomes using revascularisation and agressive drug evaluation (COURAGE) trial 

Read about the first substudy results of COURAGE.

Monthly Reviews 2007


Coronary artery calcium scores and risk for coronary events in woman classified as "low risk" based on Framingham risk score 

The multi-ethnic study of atheroscleroris (MESA) provides more insight into risk stratification by scores as compared to calcium scoring by CT
F-18-Fluorodeoxyglucose Positron Emission Tomography Imaging-Assisted Management of Patients With Severe Left Ventricular Dysfunction and Suspected Coronary Disease 
Viability testing the most important gate-keeper for revascularisation? Read the PARR-2 study


Relationship between CT coronary angiography and stress perfusion imaging in patients with suspected ischemic heart disease assessed by integrated PET-CT imaging 
"Hybrid imaging" - Additional results regarding the interrelation of anatomy and perfusion as provided by CT/PET
Radiation dose and cardiac diagnostic imaging 
Important information about radiation doses - for patients for comparison purposes


Myocardial perfusion in patients with atrial fibrillation 
This is a second review regarding myocardial perfusion in patients with atrial fibrillation and provides insight by PET techniques.
64 – Slice Computed Tomography Coronary Angiography in Patients With High, Intermediate, or Low Pretest Probability of Significant Coronary Artery Disease 
What prestest probability category patients does benefit best from cardiac computed tomography evaluation?


Prognostic Value of Multidetector coronary CT for Prediction of
All-Cause Mortality
Can coronary CT be used a prognostic tool regarding all-cause mortality?
Does myocardial perfusion SPECT risk stratify patients with atrial fibrillation? 
Patients with atrial fibrillation have a higher mortality rate regardless of their myocardial perfusion SPECT findings...


Is diabetes a silent killer for the heart? 
The incidence and prevalence of diabetes is rapidly increasing . Since coronary artery disease is the most likely cause of death in diabetic patients, screening has been debated over the last year. Read about these important points in this month's nuclear cardiology review...


Diagnostic accuracy of multidetector computed tomography coronary angiography in patients with dilated cardiomyopathy 
Dilated Cardiomyopathy is a surrogate for the final pathway of several cardiac disease processes. Patient work up to evaluate the etiology of cardiomyopathy is crucial. The presented review suggests a potential role of cardiac CT in this work up process...


Effects of Percutaneous Coronary Interventions in Silent Ischemia After Myocardial Infarction – SWISSI II 
Silent ischemia - what is the best therapeutic approach?
Silent ischemia has an important prognostic impact in patients after myocardial infarction. However, the best therapeutic strategy (intensive medical treatment or PCI) is unclear. In the SWISSI II trial (1) 201 patients with a recent MI and silent myocardial ischemia were randomized between intensive anti-ischemic drug therapy and PCI aimed at full revascularization....


"Hybrid Imaging - an important tool for decision making in coronary artery disease?" 
Hybrid imaging possibities are spreading quickly. However, is it worth the radiation and costs?


"Integrated Single Photon Emission Computed Tomography and Computed Tomography and Coronary Angiography for the Assessement of Hemodynamically Significant Coronary Artery Lesions" 
In this article, Rispler et al present their results of hybrid SPECT/CT imaging for the assessment of coronary artery lesions in a small group of 44 patients with a high prevalence of CAD (70%).


The Prognostic Value of Normal Exercise Myocardial Perfusion Imaging and Exercise Echocardiography - A Meta-Analyse 
The authors conclude that the Metz et al data further support noninvasive imaging as a core element of stable chest pain management and as an effective gatekeeper to coronary revascularization resulting in improved outcomes.

Read previous years reports here