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Luminity Contrast agent additional details

An introduction to contrast echocardiography

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CONTRAST AGENT: LUMINITY (marketed in North America as DEFINITY)
MANUFACTURER: Lantheus Medical Imaging
CONTENTS: Perflutren lipid-coated microspheres filled with octafluoropropane gas.
STORAGE: Refrigerator (2-8°C)



Preparation using the Vialmix (TM)Prior to activation, LUMINITY appears as a colour less liquid. LUMINITY needs to be ‘activated’ prior to use and this is achieved using a specific Vialmix™ device provided by the company when LUMINITY is ordered.

The Vialmix™ has a pre-defined shaking/agitation time of 45 seconds and rate of agitation, which cannot be altered. At the end of these 45 seconds, the perflutren microspheres have been created and the agent is ready for use.


A) Bolus injection

When withdrawing activated LUMINITY from the vial it is important to use a venting method. Venting avoids negative pressure in the vial and allows for easier contrast withdrawal. This can be achieved simply by inserting a standard needle into the activated vial and slowly withdrawing the contrast agent into a syringe (e.g. 3 or 5ml). Air should not be injected into the vial.
The usual initial dose is 0.3ml, which can be repeated as required to a maximum of 1.3ml.

B) Intravenous infusion

  • No specific infusion pump is available, although LUMINITY can simply be dissolved in saline or glucose and infused using a standard intravenous giving set.
  • The recommended dose is via an intravenous infusion of 1.3 ml added to 50 ml of 0.9% sodium chloride or 5% glucose solution for injection.
  • The rate of infusion should be initiated at 4.0 ml/minute, but titrated as necessary to achieve optimal image enhancement, not to exceed 10 ml/minute.