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On the left: Masson Trichrome staining On the right: SM-Aktin(brown) staining for myofibroblasts
A 12 year old girl presented with a systolic murmur when she was routinely investigated by the school doctor. For evaluating this murmur she underwent echocardiography. Here, a cardiac tumor was identified in the interventricular septum resulting in a mainly right ventricular outflow tract obstruction. The removal of the tumor (3x 2x 2 cm) by a heart surgeon was without any complications. Histopathological investigations of the tissue revealed a considerable loss of cardiomyocytes in association with a severe fibrosis (blue tissue in Masson Trichrome staining). We observed an unusual benign sinusoidal formation of structures which were CD34 negative but associated with large, focal aggregates of SM- Aktin positive myofibroblasts as demonstrated by immunohistochemistry in the right image. So far, the origin of this structural aberrance is totally unclear.
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