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Fractional flow reserve versus angiography for guiding PCI

Clinical Trial Update III

Acute Coronary Syndromes (ACS)

Presenter | see Discussant report

Nico HJ Pijls, FESC (Netherlands)

Presentation webcast

Presentation slides

List of Authors:
Nico H.J. Pijls, Pim A.L. Tonino, Bernard De Bruyne, Volker Klauss, Ganesh Manoharan, Thomas Engstrom, Peter N. Ver Lee, Philip A. MacCarthy, Keith G. Oldroyd, William F. Fearon


In patients with multivessel coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) it is unclear whether routine measurement of fractional flow reserve (FFR) in addition to angiography improves outcome.

At 20 U.S. and European medical centers, 1005 patients with multivessel CAD were randomized to PCI with drug-eluting stents (DES) guided by angiography alone or guided by FFR measurements. Prior to randomization, lesions requiring PCI were indentified based on their angiographic appearance. Patients randomized to angiography-guided PCI underwent stenting of all indicated lesions, while those randomized to FFR-guided PCI underwent stenting of indicated lesions only if FFR was <= 0.80. The primary endpoint was the rate of death, nonfatal myocardial infarction or repeat revascularisation at 1 year.

Baseline characteristics were similar. The 1-year event rate was 18.3% in the angiography-guided group and 13.2% in the FFR-guided group (P=0.02).

Further follow-up data, subgroup data, and cost-efficiency data will be shown.

Discussant | see Presenter abstract

Thomas Felix Luescher, FESC (Switzerland)

Presentation webcast

Presentation slides





Fractional flow reserve versus angiograhpy for guiding pci - 2 year outcome

Notes to editor

This congress report accompanies a presentation given at the ESC Congress 2009. Written by the author himself/herself, this report does not necessarily reflect the opinion of the European Society of Cardiology.

The content of this article reflects the personal opinion of the author/s and is not necessarily the official position of the European Society of Cardiology.