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Pooling patient data to examine the prognostic value of strain in aortic stenosis

Dr. J. Magne, Scientific Programme Advisor to EuroEcho–Imaging 2016, and CHU Limoges, Limoges, France

Dr. Magne will present the abstract “Distribution and prognostic significance of left ventricular global longitudinal strain in asymptomatic significant aortic stenosis: an individual participant data meta-analysis” during Poster session 5: Heart Valves on Friday at 14:00–18:00 in the Poster area.

“This is a project from the EACVI’s research and innovation committee, which is chaired, until December, by Prof. E. Donal, Rennes, France. We have several ongoing projects in the committee and we decided a year ago to perform a meta-analyses as we have expertise in this area.

One of the first and simplest for us to perform was this current study, which is an individual patient data meta-analysis of patients with significant but asymptomatic aortic stenosis to determine the distribution and prognostic relevance of left ventricular (LV) myocardial longitudinal function, as assessed using global longitudinal strain (GLS), which is derived from two-dimensional speckle tracking echocardiography. Our hypothesis was that GLS is superior to classical LV ejection fraction in assessing LV function.

We conducted a search of PubMed and other relevant medical databases for papers that included severe aortic stenosis patients who were asymptomatic and had a preserved LV ejection fraction, and for whom outcome data was available. For each of the studies that met the inclusion criteria, we contacted the authors to ask them to share their individual patient data, and we performed a meta-analysis of the overall dataset, with the primary end-point being mortality and the secondary endpoint combined death and cardiacrelated hospitalization, including valvular intervention.

The abstract of the study has been accepted as a poster at EuroEcho– Imaging, which will be presented on Friday, and we are preparing the manuscript. We hope to finish the first draft in December, during the congress, and will probably submit it for publication in the new year.”