Our mission is to become a worldwide reference for education in the field for all professionals involved in the process to disseminate knowledge & skills of Acute Cardiovascular Care.
Our mission is to promote excellence in clinical diagnosis, research, technical development, and education in cardiovascular imaging in Europe.
Our mission is to promote excellence in research, practice, education and policy in cardiovascular health, primary and secondary prevention.
Our mission is to reduce the burden of cardiovascular disease through percutaneous cardiovascular interventions.
Improving the quality of life and reducing sudden cardiac death by limiting the impact of heart rhythm disturbances.
Our mission is to improve quality of life and longevity, through better prevention, diagnosis and treatment of heart failure, including the establishment of networks for its management, education and research.
The ESC Working Groups' goal is to stimulate and disseminate scientific knowledge in different fields of cardiology.
The ESC Councils' goal is to share knowledge among medical professionals practising in specific cardiology domains.
OUR MISSION: TO REDUCE THE BURDEN OF CARDIOVASCULAR DISEASE
Mr Diego Franco
Heart function is orchestrated by multiple inputs. Biological insults affecting them can have profound effects on cardiac performance, leading initially to an adaptive response but eventually decompensating cardiac function. Unfortunately, the natural capacity of the adult heart to refurbish the damaged myocardium is very limited, and thus strategies to heal the heart are nowadays compulsory. Natural signalling pathways forming the heart during development will assist us to find suitable strategies as for example recent evidences demonstrating that epicardial precursors have the developmental potential to provide myocardial cells, which is nonetheless inhibited during normal embryonic development. Thus, unlocking these signals is revealed as a perfect way to regenerate the damaged heart since epicardial cells are already placed in the patient’s heart.
In this session, Prof. Thomas Brand nicely introduced the comparative developmental biology of the proepicardium, the epicardium precursors, and highlighted the distinct signalling pathways involved in epicardial development.
Bmp, Fgf and Notch signalling were revisited as well as new evidence of signal emanating from the liver anlage, in addition to the left-right signalling. Cell labelling experiments provided evidence of a heterogeneous contribution to the proepicardium, but evidence of whether such early heterogeneity is translated into distinct cell type contribution to the adult heart remains elusive.
In this context, Prof. Jose Maria Perez-Pomares provided a wonderful overview of the distinct cell contribution of the proepicardium to the adult heart, hitting on the species-specific differences and highlighting the pivotal role of Wt1 regulating several downstream signalling pathways, such as retinoic acid and pdgf. Proof-of-principle usage of epicardial layer as a regenerative tools came by with superb contributions from Dr. Nadia Mercader and Dr. Nicola Smart.
Dr. Mercader reported their latest findings using heart regeneration model after cryoinjury in the zebrafish heart, highlighting the instructive role of the epicardial derived cells to regenerate the damaged myocardium as well as to resume the initial fibrotic deposition. Dr. Smart reported the usage of thymosin beta4 as an instructive signal to the epicardium to heal the damaged mouse heart. In both contributions, understandings of the signalling pathways remain unclear but nicely exemplified the potential of the epicardium as a regenerative tool.
Developmental signals and adult heart regeneration
© 2017 European Society of Cardiology. All rights reserved