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Our mission is to reduce the burden of cardiovascular disease through percutaneous cardiovascular interventions.
Improving the quality of life and reducing sudden cardiac death by limiting the impact of heart rhythm disturbances.
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OUR MISSION: TO REDUCE THE BURDEN OF CARDIOVASCULAR DISEASE
A diagnostic strategy using computed tomographic angiography (CTA) to measure fractional flow reserve (FFRct) in suspected coronary artery disease can triage patients more effectively for subsequent invasive procedures than usual care, according to the PLATFORM study reported as a Hot Line yesterday.
While current guidelines recommend that stable chest pain patients should be evaluated with non-invasive stress testing, rates of invasive angiograms showing no obstructive CAD remain high. The recent PROMISE and SCOT-HEART trials comparing anatomic and functional strategies found that CT angiography improved processes of care but increased rates of invasive catheterisation and revascularisation with no significant reductions in events. FFRct can be derived from CTA using computational algorithms that could address such limitations by providing non invasively both functional and anatomic data. The PLATFORM study, which was published simultaneously in the European Heart Journal, thus aimed to investigate use of a CTA/FFRCT-guided strategy as compared to standard practice in reducing the rate of invasive angiograms without increasing the occurrence of major cardiac events.
In this sequential non-randomised study 584 patients with new onset chest pain and suspected CAD were prospectively assigned to either usual testing or CTA/FFRct as the next step in their diagnostic work-up. The study was performed at 11 sites.
Results showed that 73.3% of those in the usual care group had angiograms without evidence of obstructive disease, while in the FFRCT population 61% of invasive angiograms were cancelled following receipt of information from FFCct, leaving 12.4 % to proceed to invasive angiograms. The difference in the number of patients having invasive angiograms in the two groups was statistically significant (P<0.0001). No differences were found for MACE, radiation or revascularization rates.
‘Use of this combined anatomic and functional strategy employing CTA and FFRct was safe and improved patient selection for invasive catheterization,’ said study presenter Pamela Douglas, from Duke University School of Medicine in the USA.
About the European Society of CardiologyThe European Society of Cardiology (ESC) represents more than 90 000 cardiology professionals across Europe and worldwide. Its mission is to reduce the burden of cardiovascular disease in Europe. About ESC Congress 2015ESC Congress is the world’s largest and most influential cardiovascular event contributing to global awareness of the latest clinical trials and breakthrough discoveries. ESC Congress 2015 takes place 29 August to 2 September at ExCel London in London, UK. Access the scientific programme. To access all the scientific resources from the sessions during the congress, visit ESC Congress 365.
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