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Hormone replacement therapy

Presentation title: Hormone replacement therapy

Author(s): Collins P.

Date: 23 June 2005

[Download complete file]

Click a thumbnail below to view an individual slide:
		Hormone Therapy
	Available Hormone Preparations	Questions
Problems	The Past - Observation
	The Problems - Observation	The Present - Clinical Trials plus Observation
The Present	Randomized Studies	Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women
HERS TRIAL	HERS TRIAL	Primary outcome(MI & CHD death)
WHI	WHI – Healthy Women!	WHI E + P
WHI : Estrogen Alone – Hysterectomised Women	WHI (E): CHD & STARTING AGE	WHI E ALONE
WHI E + P	Hormone replacement therapy and cardiovascular disease A statement for healthcare professionals from the AHA	Summary recommendations for HRT* and CVD
Summary recommendations for HRT* and CVD	The Important Question of Age	Women Do Benefit from Lipid Lowering: Latest Clinical Trial Data
PROSPER – The HERS equivalent for Statins in women	PROSPER	PROSPER - Major Cardiovascular Outcomes According to Gender
Primary outcome(MI & CHD death) HERS vs PROSPER	Questions Still to be asked	HERS TRIAL
A clinical trial of estrogen-replacement therapy after ischemic stroke	A clinical trial of estrogen-replacement therapy after ischemic stroke	A clinical trial of estrogen-replacement therapy after ischemic stroke
Postmenopausal hormone use and secondary prevention of coronary events in the Nurse’s Health StudyA prospective, observational study	NURSES HEALTH STUDY	WHI E ALONE
Oestrogen and Myocardial Ischaemia

	17-beta-Estradiol therapy lessens angina in postmenopausal women with syndrome X.	Patients
Trial design	Trial design	Methods
Results	Episodes of chest pain	Exercise testing
Conclusions	Beneficial effect of treatment with transdermal estradiol-17-beta on exercise-induced angina and ST segment depression in syndrome X.	Trial design
Methods	Exercise testing	Conclusions

Recommendations	Esterified estrogens combined with methyltestosterone improve emotional well-being in postmenopausal women with chest pain and normal coronary angiograms.

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