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Diabetes: the complex link between inflammation, atherosclerosis and thrombosis

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Presentation title: Diabetes: the complex link between inflammation, atherosclerosis and thrombosis
Author(s): De Caterina R. (Chieti, IT)
Date: 31 August 2004
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VCAM-1 Expression in Rabbit Aorta


Vascular cell adhesion molecule 1 (VCAM-1)

Causal role of VCAM-1, but not ICAM-1, in atherosclerosis

Pro-atherogenic triggers in diabetes: the deadly trio

Candidates to pro-atherogenic agents in diabetes mellitus

High glucose promote endothelial pro-inflammatory, pro-thrombotic changes

High glucose induces VCAM-1 expression in HUVEC

High glucose and PMA induce phosphorylation at Ser660 of PKC β2

PKC inhibitor LY379196 and selective PKCβ2 inhibitor CGP53353 block glucose and PMA-induced VCAM-1 expression

Candidates to pro-atherogenic agents in diabetes mellitus

Advanced glycation endproducts: i.e.: how to transform the innocuous albumin into an inflammatory mediator


U937 cell adhesion to HSVEC


Therefore:

Candidates to pro-atherogenic agents in diabetes mellitus

Insulin resistance


The Veterans Affairs Cooperative Study on Glycemic Control and Complications in Type II Diabetes

The effects of sulfanylureas and metformin on the reduction of cardiovascular risk

Different effects of intensive vs conventional glycaemic control on micro- and macro-vascular complications in diabetes – UKPDS 33

Different effects of intensive vs conventional glycaemic control on micro- and macro-vascular complications in diabetes – UKPDS 33

Can insulin be pro-atherogenic?


Hypotheses

Insulin and NO

Nitric oxide inhibits endothelial activation






Molecular mechanisms in diabetic vasculopathy

Acknowledgements
 
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