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Complications of percutaneous coronary intervention - pathology

Print version


Presentation title: Complications of percutaneous coronary intervention - pathology
Author(s): Virmani R. (Washington, US)
Date: 29 August 2004
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Drug Coating Failures: Animal Study Results

Drug-Eluting Stents Comprise a Three-Component System

Successful Applications of DES-Major Trials

Pathology of Drug Eluting Stents in Humans



Is there a problem with Boston Scientific’s TAXUS? (NY Times 23rd April, 2004)

F.D.A. Seeks Reports of Stent Problems The New York Times April 23, 2004

Taxus Stent Thrombosis


Taxus Stent: Acute & Chronic Inflammation



Are Overlapping DES Stents Safe?

Impact of Overlapping Drug Eluting CYPHER and TAXUS Stents on Vessel Wall Morphology in Rabbits

Morphometric Measurements in the Overlapping Segment in Rabbit Iliac Arteries at 28 days


Progression of Neointimal at Overlapping Site is greater in TAXUS than CYPHER

CYPHER vs. TAXUS Overlapping DES Stent at 28 Days in Rabbit Iliac Arteries

Overlapping Stents Deployed in Rabbit Iliac arteries for 28 days

Overlapping CYPHER vs. TAXUS DES at 90 days

Granulomas were observed in Taxus and Cypher DES Stents at 90 days




Cypher with Hypersensitivity Reaction

CypherTM Stent in Left Circumflex and Left Anterior Descending Coronary Arteries and BiodivYsio Stent in Left Diagonal

Subacute Stent Thrombosis - 7 days

Causes of subacute thrombosis -CYPHER ?




Distal Stent

Causes of Adventitial, Medial and Intimal Inflammation (eosinophils) limited to the area of the Stent: Hypersensitivity reaction to drug? √ Hypersensitivity reaction to polymer? Part of atherosclerosis Infection

Granulomatous reaction seen in CYPHER Stents Implanted for 28 and 90 days in Pig Coronary Arteries

Are Polymers Benign?
 
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