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ACTION: A Coronary disease Trial Investigating Outcome with Nifedipine GITS. Discussant.

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Presentation title: ACTION: A Coronary disease Trial Investigating Outcome with Nifedipine GITS. Discussant.
Author(s): Messerli F.H. (New Orleans, US)
Date: 29 August 2004
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ACTION: Clinical Events
ACTION: Clinical Events


Completeness of follow-up
ACTION: Heart Rate and Blood Pressure

ACTION: Outcome





ACTION Predicted* versus Observed Odds Ratios (Staessen Model)
Why did blood pressure lowering with nifedipine not reduce events in ACTION?




Why did blood pressure lowering with nifedipine not reduce events in ACTION?
Why did blood pressure lowering with nifedipine not reduce events in ACTION?
Concomitant Therapy in Major Trials

Why did blood pressure lowering with nifedipine not reduce events in ACTION?




Questions About the J Curve with BP

Questions About the J Curve with BP

Low Blood Pressure is Associated with Increased Mortality and Cardiovascular Morbidity (J-shaped Curve) in Treated Hypertensive Patients With Coronary Artery Disease: The International Verapamil SR-Trandolapril Study (INVEST) Franz H. Messerli, C. Richard Conti, Giuseppe Mancia, Ann C. Hewkin, Stuart R. Kupfer, Carl J. Pepine





Conclusions
"Patients with occlusive coronary artery disease are put at risk of coronary events if diastolic pressure is low."

Conclusions
Conclusions
Conclusions

Conclusions
Conclusions
 
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